Int J Oral Biol.  2017 Sep;42(3):85-90. 10.11620/IJOB.2017.42.3.085.

The Relationship between Mitochondria and NLRP3 Inflammasome

• Lee HA
• Na HS
• Chung J

• KMID: 2394576
• DOI: http://doi.org/10.11620/IJOB.2017.42.3.085

Abstract

Mitochondria participate in various intracellular metabolic pathways such as generating intracellular ATP, synthesizing several essential molecules, regulating calcium homeostasis, and producing the cell's reactive oxygen species (ROS). Emerging studies have demonstrated newly discovered roles of mitochondria, which participate in the regulation of innate immune responses by modulating NLRP3 inflammasomes. Here, we review the recently proposed pathways to be involved in mitochondria-mediated regulation of inflammasome activation and inflammation: 1) mitochondrial ROS, 2) calcium mobilization, 3) nicotinamide adenine dinucleotide (NAD+) reduction, 4) cardiolipin, 5) mitofusin, 6) mitochondrial DNA, 7) mitochondrial antiviral signaling protein. Furthermore, we highlight the significance of mitophagy as a negative regulator of mitochondrial damage and NLRP3 inflammasome activation, as potentially helpful therapeutic approaches which could potentially address uncontrolled inflammation.

Keyword

Mitochondria; NLRP3 inflammasome; Innate immune response

MeSH Terms

Adenosine Triphosphate
Calcium
Cardiolipins
DNA, Mitochondrial
Homeostasis
Immunity, Innate
Inflammasomes*
Inflammation
Metabolic Networks and Pathways
Mitochondria*
Mitochondrial Degradation
NAD
Reactive Oxygen Species
Adenosine Triphosphate
Calcium
Cardiolipins
DNA, Mitochondrial
Inflammasomes
NAD
Reactive Oxygen Species