J Bacteriol Virol.  2013 Sep;43(3):233-234. 10.4167/jbv.2013.43.3.233.

Resistance to Chemotherapy on Tumor Through Cathepsin B-dependent Activation of the NLRP3 Inflammasome

• Kwon EJ
• Koh YS

• KMID: 2286278
• DOI: http://doi.org/10.4167/jbv.2013.43.3.233

Abstract

Anticancer drugs kill tumor cells and increase host anti-tumor immunity. Interestingly, gemcitabin (Gem) and 5-fluorouracil (5-FU), widely used anticancer drugs, lead to IL-1beta secretion releasing cathepsin B which activates Nlrp3 inflammasome in myeloid derived suppressor cells (MDSCs). MDSC derived IL-1beta enhance secretion of IL-17 by CD4+ T cells. This mechanism limits the antitumor efficacy of the drugs and promotes tumor growth.

Keyword

Gemcitabin; 5-fluorouracil; MDSCs; Nlrp3 inflammasome

MeSH Terms

Cathepsin B
Cathepsins
Fluorouracil
Interleukin-17
T-Lymphocytes
Cathepsin B
Cathepsins
Fluorouracil
Interleukin-17

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