- Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
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Chun KS, Joo SH
- KMID: 2534697
- Biomol Ther.
- 2022 Nov;30(6):479-489.
- doi: 10.4062/biomolther.2022.017
5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required... -
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- 1,3-Dibenzyl-5-Fluorouracil Prevents Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Differentiation
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Jeon H, Yu J, Hwang JM, Park HW, Yu J, Lee ZW, Kim T, Rho J
- KMID: 2536270
- Immune Netw.
- 2022 Oct;22(5):e43.
- doi: 10.4110/in.2022.22.e43
Osteoclasts (OCs) are clinically important cells that resorb bone matrix. Accelerated bone destruction by OCs is closely linked to the development of metabolic bone diseases. In this study, we screened... -
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- The Endoplasmic Reticulum Stress Response Mediates Shikonin-Induced Apoptosis of 5-Fluorouracil–Resistant Colorectal Cancer Cells
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Piao MJ, Han X, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Hyun JW
- KMID: 2529892
- Biomol Ther.
- 2022 May;30(3):265-273.
- doi: 10.4062/biomolther.2021.118
Resistance to chemotherapeutic drugs is a significant problem in the treatment of colorectal cancer, resulting in low response rates and decreased survival. Recent studies have shown that shikonin, a naphthoquinone... -
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- CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer
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Zhang G, Luo X, Zhang W, Chen E, Xu J, Wang F, Cao G, Ju Z, Jin D, Huang X, Zhou W, Song Z
- KMID: 2500346
- Cancer Res Treat.
- 2020 Apr;52(2):622-633.
- doi: 10.4143/crt.2019.593
Purpose 5-Fluorouracil (5-Fu) is used as a conventional chemotherapy drug in chemotherapy for patients with advanced colorectal cancer, but many patients still suffer from treatment failure due to 5-Fu resistance. Emerging observations revealed... -
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- Enzymes involved in folate metabolism and its implication for cancer treatment
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Kim SE
- KMID: 2471876
- Nutr Res Pract.
- 2020 Apr;14(2):95-101.
- doi: 10.4162/nrp.2020.14.2.95
BACKGROUND/OBJECTIVES: Folate plays a critical role in DNA synthesis and methylation. Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and γ-glutamyl hydrolase (GGH). FPGS adds glutamate residues... -
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- Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway
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Lee JH, Yun CW, Lee SH
- KMID: 2421741
- Biomol Ther.
- 2018 May;26(3):313-321.
- doi: 10.4062/biomolther.2017.033
Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive.... -
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- Clinical outcomes and risk of recurrence among patients with vaginal intraepithelial neoplasia: a comprehensive analysis of 576 cases
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Kim MK, Lee IH, Lee KH
- KMID: 2395233
- J Gynecol Oncol.
- 2018 Jan;29(1):e6.
- doi: 10.3802/jgo.2018.29.e6
OBJECTIVE: To evaluate the clinical outcomes of vaginal intraepithelial neoplasia (VAIN) and to assess the risk of recurrence and progression to invasive vaginal carcinoma. METHODS: A retrospective review of the clinicopathologic... -
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- The outcomes of intensified 5-fluorouracil plus leucovorin chemotherapy for preoperative chemoradiation in rectal cancers
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Ha N, Hong KD, Ji WB, Kim JS, Um JW
- KMID: 2405657
- Korean J Clin Oncol.
- 2017 Dec;13(2):147-151.
- doi: 10.14216/kjco.17023
PURPOSE: The clinical benefit of intensified neoadjuvant chemoradiotherapy (CRT) in rectal cancer has not been proved. We investigated clinical outcomes of intensified 5-fluorouracil plus leucovorin (5-FU/LV) chemotherapy. METHODS: We retrospectively analyzed... -
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- Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells
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Yao CW, Kang KA, Piao MJ, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Na SY, Jeong SU, Boo SJ, Hyun JW
- KMID: 2378810
- Biomol Ther.
- 2017 May;25(3):315-320.
- doi: 10.4062/biomolther.2016.069
We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5-FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and... -
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- The Effectiveness of Topical Chemotherapy for the Primary Treatment of Ocular Surface Squamous Neoplasia
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Kim IG, Yu S, Lee GJ, Lee KW, Park YJ
- KMID: 2369461
- J Korean Ophthalmol Soc.
- 2017 Feb;58(2):147-155.
- doi: 10.3341/jkos.2017.58.2.147
PURPOSE: In the present study, the effectiveness of topical chemotherapy for the primary treatment of ocular surface squamous neoplasia (OSSN) was evaluated. METHODS: We enrolled 10 patients (10 eyes) diagnosed with... -
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- Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin
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Lee J, Kang JS, Choi BY, Keum YS
- KMID: 2374614
- Biomol Ther.
- 2016 Nov;24(6):604-609.
- doi: 10.4062/biomolther.2016.028
5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding... -
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- Efficacy and Safety of Bolus 5-Fluorouracil and L-Leucovorin as Salvage Chemotherapy for Oral Fluoropyrimidine-Resistant Unresectable or Recurrent Gastric Cancer: A Single Center Experience
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Muranaka T, Yuki S, Komatsu Y, Sawada K, Harada K, Kawamoto Y, Nakatsumi , Sakamoto N
- KMID: 2372561
- J Gastric Cancer.
- 2016 Sep;16(3):177-181.
- doi: 10.5230/jgc.2016.16.3.177
PURPOSE: The International Organization for Standardization-5fluorouracil (FU) 10 trial found that bolus 5-FU and l-leucovorin was not inferior to S-1 in the treatment of gastric cancer (GC). Continuous 5-FU and... -
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- Effect of Mixed Injection of Botulinum Neurotoxin, Triamcinolone and 5-Fluorouracil in Graves' Upper Eyelid Retraction
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Sung YJ, Park JS, Lew H
- KMID: 2212709
- J Korean Ophthalmol Soc.
- 2016 May;57(5):691-699.
- doi: 10.3341/jkos.2016.57.5.691
PURPOSE: The aim of this study is to evaluate the effects and complications of mixed injections of botulinum neurotoxin A (BoNT-A), triamcinolone acetonide, 5-fluorouracil (5-FU) in patients with Graves upper... -
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- Ahmed Valve Implant Surgery with Adjunctive Mitomycin C and Selective 5-Fluorouracil Injection
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Yun IS, Lee JD, Kim YH, Ahn JH
- KMID: 2213249
- J Korean Ophthalmol Soc.
- 2016 Mar;57(3):468-476.
- doi: 10.3341/jkos.2016.57.3.468
PURPOSE: To evaluate the surgical results of Ahmed valve implant surgery with adjunctive mitomycin C and selective postoperative 5-fluorouracil (5-FU) subconjunctival injection with a needling procedure. METHODS: In this retrospective study,... -
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- Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
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Yi HJ, Hong KS, Moon N, Chung SS, Lee RA, Kim KH
- KMID: 2155052
- Ann Surg Treat Res.
- 2016 Mar;90(3):179-182.
- doi: 10.4174/astr.2016.90.3.179
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and... -
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- Risk Factors and Efficacy of Adjuvant Therapy After Surgery of Elderly Colon Cancer Patients 70 Years of Age or Older
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Park SE, Ha JY, Cha SJ, Jang JS, Hwang IG
- KMID: 2188188
- J Korean Geriatr Soc.
- 2015 Sep;19(3):165-175.
- doi: 10.4235/jkgs.2015.19.3.165
BACKGROUND: Colon cancer affects largely elderly populations. Elderly patients treated with adjuvant chemotherapy is lower than younger patients in colon cancer. We aim to evaluate the survival and prognostic factors... -
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- Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-bearing mice
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Cao Z, Chen X, Lan L, Zhang Z, Du J, Liao L
- KMID: 2313820
- Nutr Res Pract.
- 2015 Apr;9(2):129-136.
- doi: 10.4162/nrp.2015.9.2.129
BACKGROUND/OBJECTIVES: A variety of immunomodulators can improve the efficacy of low-dose chemotherapeutics. Active hexose correlated compound (AHCC), a mushroom mycelia extract, has been shown to be a strong immunomodulator. Whether... -
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- Resistance to Chemotherapy on Tumor Through Cathepsin B-dependent Activation of the NLRP3 Inflammasome
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Kwon EJ, Koh YS
- KMID: 2286278
- J Bacteriol Virol.
- 2013 Sep;43(3):233-234.
- doi: 10.4167/jbv.2013.43.3.233
Anticancer drugs kill tumor cells and increase host anti-tumor immunity. Interestingly, gemcitabin (Gem) and 5-fluorouracil (5-FU), widely used anticancer drugs, lead to IL-1beta secretion releasing cathepsin B which activates Nlrp3... -
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- A Case of Cardiogenic Shock after Chemotherapy with 5-Fluorouracil and Leucovorin in Rectal Cancer
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Yoon JH, Kim DH, Kim SH, Choi W, Koh YI, Chung IJ, Bae WK
- KMID: 2264576
- Korean J Med.
- 2012 Oct;83(4):525-528.
A 51-year-old man with rectal adenocarcinoma was admitted to hospital for neoadjuvant concurrent chemoradiotherapy. Three days after receiving 5-fluorouracil (425 mg/m2) and leucovorin (20 mg/m2) chemotherapy, the patient complained of... -
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- Synergistic Effect of Parthenolide in Combination with 5-Fluorouracil in SW480 Cells
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Kim SL, Kieu TT, Jeon BJ, Kim SH, Kim IH, Lee SO, Lee ST, Kim SW
- KMID: 2174252
- Intest Res.
- 2012 Oct;10(4):357-364.
- doi: 10.5217/ir.2012.10.4.357
BACKGROUND/AIMS: Parthenolide (PT) is responsible for the bioactivities of Feverfew. Besides its potent anti-inflammatory effect, this compound has recently been reported to induce apoptosis in cancer cells. Unfortunately, many of... -
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