J Neurogastroenterol Motil.  2017 Jul;23(3):415-427. 10.5056/jnm16148.

Mapping of Brain Activations to Rectal Balloon Distension Stimuli in Male Patients with Irritable Bowel Syndrome Using Functional Magnetic Resonance Imaging

• Guleria A
• Karyampudi A
• Singh R
• Khetrapal
• Verma A
• Ghoshal UC
• Kumar D

• KMID: 2387833
• DOI: http://doi.org/10.5056/jnm16148

Abstract

BACKGROUND/AIMS
Irritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is scanty among males. Hence, we aimed to study brain response of male IBS patients following rectal balloon distension as compared to healthy controls using functional magnetic resonance imaging (fMRI). Data between diarrhea and constipation predominant IBS (IBS-D and IBS-C) were also compared.
METHODS
Rectal balloon distension threshold was assessed in 20 male IBS patients (10 IBS-C and 10 IBS-D) and 10 age-matched male healthy controls. Subsequently, fMRI on all the participants was performed at their respective rectal pain threshold. The fMRI data were analysed using the Statistical Parametric Mapping software.
RESULTS
IBS patients showed greater cerebral activations in insula, middle temporal gyrus, and cerebellum in the left hemisphere compared to healthy controls. Neural activation was found in bilateral precuneus/superior parietal lobules in controls but not in patients with IBS. The brain activation differed among IBS-C and IBS-D patients; while the right mid-cingulate cortex was activated in IBS-C, the left inferior orbito-frontal cortex, left calcarine, and bilateral fusiform gyri were activated among patients with IBS-D following rectal balloon distension.
CONCLUSIONS
Brain response to rectal balloon distension differed among male patients with IBS and controls and among patients with IBS-C and IBS-D. Differential activation among patients with IBS-C and IBS-D was seen in the brain regions controlling affective motivation, homeostatic emotions, and autonomic responses to pain.

Keyword

Brain; Irritable bowel syndrome; Magnetic resonance imaging; Pain

MeSH Terms

Brain*
Cerebellum
Constipation
Diarrhea
Female
Humans
Irritable Bowel Syndrome*
Magnetic Resonance Imaging*
Male*
Motivation
Pain Threshold
Parietal Lobe
Temporal Lobe