Exp Mol Med.
2017 Jun;49(6):e349. 10.1038/emm.2017.81.
Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice
- Affiliations
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- 1Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. tykimder@catholic.ac.kr
- 2Department of Dermatology, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea.
- 3Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
- KMID: 2386969
- DOI: http://doi.org/10.1038/emm.2017.81
Abstract
- Many active compounds present in Rhododendron brachycarpum have been used in traditional Oriental medicine for the treatment of various skin diseases. However, the precise mechanism of action of the compounds isolated from R. brachycarpum and their relevance as therapeutics for the treatment of psoriasis remain elusive. In this study, we report that rhododendrin isolated from R. brachycarpum strongly inhibits imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice. We showed that topical treatment with rhododendrin reduces IMQ-induced skin hyperplasia, inflammatory mononuclear cell infiltration and the expression of pro-inflammatory mediators in mouse skin. In addition, we found that rhododendrin inhibits the activation of the TLR-7/NF-κB and mitogen-activated protein kinase pathways in both IMQ-induced psoriasis-like skin inflammation in mice and in normal human epidermal keratinocytes treated with IMQ. These results suggest that rhododendrin has an anti-inflammatory effect and can be used as a therapeutic to fight against psoriasis and other inflammatory skin diseases.
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