J Bacteriol Virol.  2011 Jun;41(2):131-132. 10.4167/jbv.2011.41.2.131.

Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation

• Koh YS

• KMID: 2168631
• DOI: http://doi.org/10.4167/jbv.2011.41.2.131

Abstract

Toll-like receptor 9 binds to DNA from bacteria or viruses and activates a signaling pathway that leads to the induction of proinflammatory cytokines and type I interferon. Adaptor complex AP-3 was required for TLR9 trafficking and the production of type I interferon but not for proinflammatory cytokines. This suggests that TLR9 signaling is regulated by the subcellular localization of the receptor.

Keyword

Toll-like receptor 9; Membrane trafficking; Adaptor complex AP-3

MeSH Terms

Bacteria
Cytokines
DNA
Interferon Type I
Toll-Like Receptor 9
Toll-Like Receptors
Cytokines
DNA
Interferon Type I
Toll-Like Receptor 9
Toll-Like Receptors

Reference

1). Sasai M., Linehan MM., Iwasaki A. Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science. 2010. 329:1530–4.

2). Janeway CA Jr., Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002. 20:197–216.

3). Tabeta K., Hoebe K., Janssen EM., Du X., Georgel P., Crozat K, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol. 2006. 7:156–64.

4). Kim YM., Brinkmann MM., Paquet ME., Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 2008. 452:234–8.

5). Ewald SE., Lee BL., Lau L., Wickliffe KE., Shi GP., Chapman HA, et al. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature. 2008. 456:658–62.