J Bacteriol Virol.  2011 Jun;41(2):131-132. 10.4167/jbv.2011.41.2.131.

Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation

• Koh YS

• KMID: 2168631
• DOI: http://doi.org/10.4167/jbv.2011.41.2.131

Abstract

Toll-like receptor 9 binds to DNA from bacteria or viruses and activates a signaling pathway that leads to the induction of proinflammatory cytokines and type I interferon. Adaptor complex AP-3 was required for TLR9 trafficking and the production of type I interferon but not for proinflammatory cytokines. This suggests that TLR9 signaling is regulated by the subcellular localization of the receptor.

Keyword

Toll-like receptor 9; Membrane trafficking; Adaptor complex AP-3

MeSH Terms

Bacteria
Cytokines
DNA
Interferon Type I
Toll-Like Receptor 9
Toll-Like Receptors
Cytokines
DNA
Interferon Type I
Toll-Like Receptor 9
Toll-Like Receptors