J Korean Soc Pediatr Endocrinol.  2011 Aug;16(2):86-91.

Clinical Course of Childhood Onset Pseudoprecocious Puberty due to Autonomous Ovarian Cyst

• Kim MJ
• Jung HJ
• Choi IJ
• Hong SY

Abstract

PURPOSE
There are few reports about the natural history of patients with pseudoprecocious puberty due to autonomous ovarian cyst. We reviewed the clinical course of 7 patients who had autonomous ovarian cysts and signs of precocious puberty.
METHODS
We retrospectively evaluated 7 children, aged 2.8 to 7.9 years, who were diagnosed with pseudoprecocious puberty due to autonomous ovarian cysts from November 2005 to May 2011. The follow-up durations ranged from 0.5 to 6.3 years.
RESULTS
Four out of 7 patients showed elevated serum estrogen levels and all revealed prepubertal response of gonadotropin to GnRH stimulation at diagnosis. The size of the cysts was from 1.7 to 4.6 cm on pelvic ultrasound examination. After 1 to 3 months, the ovarian cysts disappeared in all patients. Three of the girls developed relapsing signs of precocious puberty (vaginal bleeding and breast budding). Two of them showed an increase in growth velocity and bone age due to recurrent ovarian cysts, and one of them was converted to true precocious puberty.
CONCLUSION
In our cases, all patients with autonomous ovarian cysts resolved spontaneously. However, some showed frequent recurrence of ovarian cysts, and needed a longer follow up because of the possibility of conversion to true precocious puberty and signs of McCune-Albright syndrome.

Keyword

Puberty, precocious; Ovarian cysts

MeSH Terms

Aged
Breast
Child
Estrogens
Female
Fibrous Dysplasia, Polyostotic
Follow-Up Studies
Gonadotropin-Releasing Hormone
Gonadotropins
Hemorrhage
Humans
Natural History
Ovarian Cysts
Puberty
Puberty, Precocious
Recurrence
Retrospective Studies
Estrogens
Gonadotropin-Releasing Hormone
Gonadotropins