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Basal serum luteinizing hormone value as the screening biomarker in female central precocious puberty

Heo S, Lee YS, Yu J

PURPOSE: Precocious puberty refers to the development of secondary sex characteristics before ages 8 and 9 years in girls and boys, respectively. Central precocious puberty (CPP) is caused by premature...
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Methylphenidate and Central Precocious Puberty: A Probable Side Effect among Seven Children with the Attention Deficit Hyperactivity Disorder

Ergür AT, Gül H, Gül A

Methylphenidate (MPH) is the most preferred drug for treatment of the attention deficit hyperactivity disorder (ADHD). Here, we aimed to discuss the possible effects and mechanisms of MPH on precocious...
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Thyroid function in girls with central precocious puberty

Jung G, Oh SB, Lee WY, Kim HR, Nam HK, Kim JH, Rhie YJ, Lee KH

PURPOSE: Obesity is a well-known risk factor for central precocious puberty (CPP). Recently, elevated thyroid stimulating hormone (TSH) was reported in obese youth. However, few data regarding the relationship between...
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Comparing adult height gain and menarcheal age between girls with central precocious puberty treated with gonadotropin-releasing hormone agonist alone and those treated with combined growth hormone therapy

Kim MS, Koh HJ, Lee GY, Kang DH, Kim SY

PURPOSE: This study aimed to investigate the outcomes of gonadotropin-releasing hormone agonist (GnRHa) therapy with or without growth hormone (GH) therapy for girls with idiopathic central precocious puberty (CPP). METHODS: The...
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Episodes of prolonged “trance-like state” in an infant with hypothalamic hamartoma

Kumar R, Yadav J, Sahu JK, Tripathi M, Ahuja C, Dayal D

Hypothalamic hamartoma (HH) is one of the most common causes of central precocious puberty (CPP) in first few years of life. It can present with either seizures or CPP, although...
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Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty

Lee DM, Chung IH

PURPOSE: The standard method used to diagnose central precocious puberty (CPP) is the gonadotropin releasing hormone stimulation test (GnRHST). However, this test is inconvenient for children because it is time-consuming...
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Experiences of Precocious Puberty in Primary School Girls with Hormone Therapeutics

Cheon SM, Jung HY

PURPOSE: The purpose of this qualitative study was to identify the nature of precocious puberty and to explore what it means in primary schools. METHODS: The participants of this phenomenological study...
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Herlyn-Werner-Wunderlich Syndrome with Central Precocious Puberty: A Case Report

Han J, Lee JM, Kim GH, Kim SJ

Herlyn-Werner-Wunderlich (HWW) syndrome is a rare congenital anomaly of the genitourinary tract comprising uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Patients with HWW syndrome usually present symptoms such as...
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Depression and Fear about Maturation in Girls with Precocious Puberty and Depression and Anxiety in Their Mothers

Lee MJ, Baek SH, Park SA

PURPOSE: This study investigated depression and anxiety in girls with precocious puberty and in their mothers. METHOD: This study recruited 75 girls treated with a gonadotropin-releasing hormone agonist (GnRHa) and their...
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Visceral fat thickness and its associations with pubertal and metabolic parameters among girls with precocious puberty

Kim DW, Suh J, Kwon AR, Chae HW, Yoon CS, Kim HS, Kim DH

PURPOSE: This study aimed to investigate associations of central obesity with sexual maturation and metabolic parameters in Korean girls with precocious puberty. METHODS: This retrospective study evaluated data from 72 girls...
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Etiological trends in male central precocious puberty

Lee J, Kim J, Yang A, Cho SY, Jin DK

PURPOSE: In the present study, the etiological trends in male central precocious puberty (CPP) were examined, and annual distribution was evaluated. METHODS: Seventy-one male CPP subjects who started puberty before 9...
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A Case Report of Precocious Puberty in Children Associated with Hypothalamic Hamartoma in Neurofibromatosis Type 1

Lee SA, Kim JH, Kim SJ

Neurofibromatosis type 1 (NF1) is a common neurocutaneous syndrome that presents with multiple café-au-lait spots, skinfold freckling, dermatofibromas, neurofibromas, and Lisch nodules. Mutations of the NF1 gene, encoding the protein...
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Longitudinal follow-up to near final height of auxological changes in girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analog and grouped by pretreatment body mass index level

Park J, Hwang TH, Kim YD, Han HS

PURPOSE: Reported changes in body mass index (BMI) in central precocious puberty (CPP) during and after gonadotropin-releasing hormone analog (GnRHa) treatment are inconsistent. We, therefore, investigated auxological parameters in GnRHa-treated...
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The effect of overweight on the luteinizing hormone level after gonadorelin stimulation test in girls with idiopathic central precocious puberty

Lee HY, Lee YJ, Ahn MB, Cho WK, Suh BK

PURPOSE: We investigated the effect of overweight on luteinizing hormone (LH) levels after a gonadorelin stimulation test in Korean girls with idiopathic central precocious puberty (CPP). METHODS: Medical records of 234...
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Prevalence of Pathological Brain Lesions in Girls with Central Precocious Puberty: Possible Overestimation?

Yoon JS, So CH, Lee HS, Lim JS, Hwang JS

BACKGROUND: Brain magnetic resonance imaging (MRI) is routinely performed to identify brain lesions in girls with central precocious puberty (CPP). We aimed to investigate the prevalence and type of brain...
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Etiology and treatment of central precocious puberty

Kim SY

The timing of pubertal onset is occurring at younger ages. This phenomenon is associated with many environmental factors such as sufficient nutrition, stress, many kinds of endocrine-disrupting chemicals, and genetic...
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A Case of a Girl with Arnold-Chiari Type 1 Malformation with Precocious Puberty

Kim MS, Hwang PH, Lee DY

A small percentage of individuals have the neurological anomaly of central precocious puberty (CPP). Common neurologic causes of CPP include a tumor or congenital lesions. Although Arnold-Chiari malformation can be...
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Diurnal variation of gonadotropin levels in girls with early stages of puberty

Kang YS, Yoo DY, Chung IH, Yoo EG

PURPOSE: Pubertal gonadotropin secretion shows circadian pattern and the luteinizing hormone (LH) levels tend to rise in later stages of puberty in girls. We studied the usefulness of basal LH...
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Insulin resistance and bone age advancement in girls with central precocious puberty

Hur JH, Park S, Jung MK, Kang SJ, Kwon A, Chae HW, Kim HS, Kim DH

PURPOSE: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study...
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Factors Influencing the Quality of Life in Mothers of Children with Precocious Puberty

Lee S, Kim G

PURPOSE: In this study factors affecting quality of life in mothers who have children with precocious puberty were identified. METHODS: The participants were 102 mothers of children with precocious puberty. From...
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