J Mov Disord.
2017 May;10(2):69-79. 10.14802/jmd.16061.
Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease
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- 1Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. brzhang@zju.edu.cn
- KMID: 2379639
- DOI: http://doi.org/10.14802/jmd.16061
Abstract
- Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
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