- Alpha-Synuclein Function and Dysfunction on Cellular Membranes
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Snead D, Eliezer D
- KMID: 2165535
- Exp Neurobiol.
- 2014 Dec;23(4):292-313.
- doi: 10.5607/en.2014.23.4.292
Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein cause autosomal dominant early onset... -
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- Accumulation of Alpha-synuclein Causes Colonic Dysmotility Independently of Enteric Nervous Damage in the Early Stage of Parkinson's Disease (Neurogastroenterol Motil 2012;24:e425-e436)
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Kim YS
- KMID: 2325802
- J Neurogastroenterol Motil.
- 2013 Apr;19(2):264-266.
No abstract available. -
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- Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease
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Si X, Pu J, Zhang B
- KMID: 2379639
- J Mov Disord.
- 2017 May;10(2):69-79.
- doi: 10.14802/jmd.16061
Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including... -
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- ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy
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Lopes da Fonseca T, Outeiro TF
- KMID: 2165536
- Exp Neurobiol.
- 2014 Dec;23(4):314-323.
- doi: 10.5607/en.2014.23.4.314
Parkinson's Disease (PD) is a complex and multifactorial disorder of both idiopathic and genetic origin. Thus far, more than 20 genes have been linked to familial forms of PD. Two... -
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- Topographical Propagation of alpha-synuclein Pathology in Parkinson's Disease: Phenomenology and Hypothetical Mechanism
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Hyun M, Lee SJ
- KMID: 2165292
- Exp Neurobiol.
- 2009 Jun;18(1):19-25.
- doi: 10.5607/en.2009.18.1.19
Parkinson's disease is an age-related, slowly progressing neurodegenerative disorder characterized by abnormal deposition of aggregated alpha-synuclein in neuronal cell bodies (Lewy bodies) and neurites (Lewy neurites), as well as in... -
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- Elevated Levels of alpha-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naive Patients with Parkinson's Disease
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Park MJ, Cheon SM, Bae HR, Kim SH, Kim JW
- KMID: 2179007
- J Clin Neurol.
- 2011 Dec;7(4):215-222.
- doi: 10.3988/jcn.2011.7.4.215
BACKGROUND AND PURPOSE: The detection of alpha-synuclein in the body fluids of patients with synucleinopathy has yielded promising but inconclusive results, in part because of conformational changes of alpha-synuclein in... -
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- Protein Transmission, Seeding and Degradation: Key Steps for alpha-Synuclein Prion-Like Propagation
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Oueslati A, Ximerakis , Vekrellis
- KMID: 2165537
- Exp Neurobiol.
- 2014 Dec;23(4):324-336.
- doi: 10.5607/en.2014.23.4.324
Converging lines of evidence suggest that cell-to-cell transmission and the self-propagation of pathogenic amyloidogenic proteins play a central role in the initiation and the progression of several neurodegenerative disorders. This... -
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- Alpha-Synuclein Expression in Patients with Parkinson's Disease: A Clinician's Perspective
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Kim HJ
- KMID: 1427105
- Exp Neurobiol.
- 2013 Jun;22(2):77-83.
- doi: 10.5607/en.2013.22.2.77
Although physiological function of alpha-synuclein is not yet clearly understood, accumulating evidence strongly suggests it plays a crucial role in the pathogenesis of Parkinson disease. Pathologically, alpha-synuclein is a major... -
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- Multiple System Atrophy: Genetic or Epigenetic?
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Sturm E, Stefanova
- KMID: 2165534
- Exp Neurobiol.
- 2014 Dec;23(4):277-291.
- doi: 10.5607/en.2014.23.4.277
Multiple system atrophy (MSA) is a rare, late-onset and fatal neurodegenerative disease including multisystem neurodegeneration and the formation of alpha-synuclein containing oligodendroglial cytoplasmic inclusions (GCIs), which present the hallmark of... -
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- Inclusion Body Formation and Apoptotic Cell Death in the Human Neural Stem Cells HB1.F3 Following Gene Transfection of Alpha-Synuclein and Synphilin-1
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Cheon SM, Lee G, Kim JW, Kim SU
- KMID: 2343254
- J Korean Neurol Assoc.
- 2007 Aug;25(3):344-352.
BACKGROUND: The etiology of Parkinson's disease (PD) has not been established, but familial forms of the disease have some clues for its pathogenesis. Autosomal dominantly inherited familial PD induced by... -
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- The Effects of Recombinant Synucleins and Insulin-like Growth Factor 1 on Cancer Cell Migration
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Shin W, Kim J
- KMID: 1717684
- J Bacteriol Virol.
- 2012 Jun;42(2):133-151.
- doi: 10.4167/jbv.2012.42.2.133
The synuclein family consists of three distinct genes, alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha-synuclein and beta-synuclein are predominately expressed in brain and especially alpha-synuclein is related with Parkinson's disease, Alzheimer's... -
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- Identification and Localization of Alpha-Synuclein in Human Cornea
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Hong S, Lee HK, Kim CY, Seong GJ
- KMID: 1099012
- Korean J Ophthalmol.
- 2008 Jun;22(2):145-146.
- doi: 10.3341/kjo.2008.22.2.145
No abstract available. -
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- Point Mutations at alpha-Synuclein Gene are not Found in Korean Familial Parkinson's Disease
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Lyoo CH, Kim HS, Kim YD, Kim JH, Lee MS
- KMID: 1905133
- J Korean Neurol Assoc.
- 1999 Jul;17(4):534-540.
BACKGROUND: Recent developments of molecular biological techniques have enabled the identification of genetic abnormalities responsible for the development of familial Parkinson's disease (PD). The alpha-synuclein, a major component of Lewy... -
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- Valproic Acid Regulates alpha-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes
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Kim JN, Kim MK, Cho KS, Choi CS, Park SH, Yang SI, Joo SH, Park JH, Bahn G, Shin CY, Lee HJ, Han SH, Kwon KJ
- KMID: 1502491
- Biomol Ther.
- 2013 May;21(3):222-228.
Although the role of alpha-synuclein aggregation on Parkinson's disease is relatively well known, the physiological role and the regulatory mechanism governing the expression of alpha-synuclein are unclear yet. We recently... -
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- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
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Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ
- KMID: 1104391
- Exp Mol Med.
- 2011 Apr;43(4):216-222.
- doi: 10.3858/emm.2011.43.4.026
Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have... -
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- LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease
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Hyun CH, Yoon CY, Lee HJ, Lee SJ
- KMID: 2284628
- Exp Neurobiol.
- 2013 Dec;22(4):249-257.
- doi: 10.5607/en.2013.22.4.249
Parkinson's disease (PD) and related Lewy body diseases are characterized by deposition of alpha-synuclein aggregates in both the central nervous system and peripheral nervous system. Synucleinopathy lesions spread to larger... -
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- Amyloidogenic Protein of alpha-Synuclein
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Yang JE, Paik SR
- KMID: 2168245
- Hanyang Med Rev.
- 2013 May;33(2):123-129.
- doi: 10.7599/hmr.2013.33.2.123
Amyloidogenesis is the key pathological phenomenon commonly observed in various neurodegenerative disorders. alpha-Synuclein is the major constituent of Lewy bodies as a common pathological signature of Lewy body diseases (LBDs)... -
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- Dementia with Lewy Bodies
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Kim SG, Jung HY
- KMID: 2334057
- J Korean Geriatr Psychiatry.
- 2007 Dec;11(2):62-72.
Here the author reviews the clinical and pathologic characteristics of dementia with Lewy bodies (DLB). DLB took many years to crystallize into a recognizable clinico-pathologic entity. Based on sensitive immunostaining... -
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- Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein
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Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ
- KMID: 2154241
- Exp Mol Med.
- 2013 May;45(5):e22.
The accumulation of abnormal protein aggregates is a major characteristic of many neurodegenerative disorders, including Parkinson's disease (PD). The intracytoplasmic deposition of alpha-synuclein aggregates and Lewy bodies, often found in... -
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- Alpha-Synuclein in Skin Nerve Fibers as a Biomarker for Alpha-Synucleinopathies
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Kim JY, Illigens B, McCormick , Wang N, Gibbons CH
- KMID: 2467725
- J Clin Neurol.
- 2019 Apr;15(2):135-142.
- doi: 10.3988/jcn.2019.15.2.135
The common pathological features of synucleinopathies are abnormal aggregates of the synaptic protein alpha-synuclein (αSN) in the cytoplasm of neurons or glia. These abnormal aggregates appear several years before the... -
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