Korean J Phys Anthropol.  1994 Dec;7(2):171-186. 10.11637/kjpa.1994.7.2.171.

Immunohistochemical Localization of a Dopamine Releasing Protein in Human Brain

• Shin KY
• Bae SD
• Kim JJ
• Nau SM
• Kim MO
• Cho KJ
• Lee BH
• Choi WS
• Sohn HJ
• Baik SH

• KMID: 2377165
• DOI: http://doi.org/10.11637/kjpa.1994.7.2.171

Abstract

In order to elucidate the existence and locality of DARP in the human brain, immunohistochemical identification was done in the brain tissues. This glycoprotein was distributed in paraventricular nucleus and thalamic reticular nucleus of diencephalon, substantia nigra and inferior colliculus of mesencephalon, medial vestibular nucleus, medial longitudinal nucleus, lateral reticular nucleus of medulla oblongata. And they follows a close distribution to that of catecholamine (CA) rich in either CA fiber or CA neuronal cell groups as previously reported by others using tyrosine hydroxylase (TH) as a marker. This striking similarities in the topographic arrangement of the DARP-positive reaction product and the TH-positive reaction product is another argument favoring the view that DARP is involved in the regulation of catecholaminergic neurons.

Keyword

DARP; CNS; Immunohistochemisiry; Human

MeSH Terms

Brain*
Diencephalon
Dopamine*
Glycoproteins
Humans*
Inferior Colliculi
Medulla Oblongata
Mesencephalon
Neurons
Paraventricular Hypothalamic Nucleus
Strikes, Employee
Substantia Nigra
Tyrosine 3-Monooxygenase
Vestibular Nuclei
Dopamine
Glycoproteins
Tyrosine 3-Monooxygenase