- Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources
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Hwang DJ, Kwon KC, Song HK, Kim KS, Jung YS, Hwang DY, Cho JY
- KMID: 2470109
- Lab Anim Res.
- 2019 Aug;35(2):61-69.
- doi: 10.1186/s42826-019-0012-2
MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson's disease (PD), with use in numerous PD models... -
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- HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
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Kim T, Song S, Park Y, Kang S, Seo H
- KMID: 2458548
- Exp Neurobiol.
- 2019 Aug;28(4):504-515.
- doi: 10.5607/en.2019.28.4.504
Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors.... -
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- 7,8,4′-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells
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Ko YH, Kim SK, Kwon SH, Seo JY, Lee BR, Kim YJ, Hur KH, Kim SY, Lee SY, Jang CG
- KMID: 2455091
- Biomol Ther.
- 2019 Jul;27(4):363-372.
- doi: 10.4062/biomolther.2018.211
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4′-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine... -
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- Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPPâº-lesioned Rats via Ciliary Neurotrophic Factor
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Kim KI, Baek JY, Jeong JY, Nam JH, Park ES, Bok E, Shin WH, Chung YC, Jin BK
- KMID: 2450220
- Exp Neurobiol.
- 2019 Apr;28(2):289-299.
- doi: 10.5607/en.2019.28.2.289
Transient receptor potential vanilloid subtype 1 (TRPV1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (DA) neurons in MPPâº-lesioned rats via ciliary neurotrophic factor (CNTF). The present study determined whether... -
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- Change of Extracellular Glutamate Level in Striatum during Deep Brain Stimulation of the Entopeduncular Nucleus in Rats
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Lee HJ, Sung JH, Hong JT, Kim IS, Yang SH, Cho CB
- KMID: 2441560
- J Korean Neurosurg Soc.
- 2019 Mar;62(2):166-174.
- doi: 10.3340/jkns.2018.0122
OBJECTIVE: Globus pallidus interna (GPi) is acknowledged as an essential treatment for advanced Parkinson’s disease (PD). Nonetheless, the neurotransmitter study about its results is undiscovered. The goal of this research... -
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- Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
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Park JS, Leem YH, Park JE, Kim DY, Kim HS
- KMID: 2442009
- Biomol Ther.
- 2019 Feb;27(2):178-184.
- doi: 10.4062/biomolther.2018.234
Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a... -
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- Ganglion cardiacum or juxtaductal body of human fetuses
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Kim JH, Cho KH, Jin ZW, Murakami G, Abe H, Chai OH
- KMID: 2430194
- Anat Cell Biol.
- 2018 Dec;51(4):266-273.
- doi: 10.5115/acb.2018.51.4.266
The ganglion cardiacum or juxtaductal body is situated along the left recurrent laryngeal nerve in the aortic window and is an extremely large component of the cardiac nerve plexus. This... -
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- Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] Mouse Line in Various Brain Regions
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Park YM, Chun H, Shin JI, Lee CJ
- KMID: 2430108
- Exp Neurobiol.
- 2018 Dec;27(6):508-525.
- doi: 10.5607/en.2018.27.6.508
Astrocyte is the most abundant cell type in the central nervous system and its importance has been increasingly recognized in the brain pathophysiology. To study in vivo function of astrocyte,... -
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- Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice
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Moon EJ, Ko IG, Kim SE, Jin JJ, Hwang L, Kim CJ, An H, Lee BJ, Yi JW
- KMID: 2426692
- Int Neurourol J.
- 2018 Oct;22(Suppl 3):S139-S146.
- doi: 10.5213/inj.1836228.114
PURPOSE: Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect. In this study, the action of dexmedetomidine on sleep... -
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- Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo
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Bok E, Cho EJ, Chung ES, Shin WH, Jin BK
- KMID: 2419340
- Exp Neurobiol.
- 2018 Aug;27(4):309-319.
- doi: 10.5607/en.2018.27.4.309
The present study investigated the effects of interleukin (IL)-4 on dopamine (DA) neurons in the substantia nigra (SN) in vivo of lipopolysaccharide (LPS)-treated rat. Tyrosine hydroxylase immunohistochemistry showed a significant... -
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- Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
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Davaasambuu U, Park KH, Park HJ, Choi HS, Lee CK, Hwang BY, Lee MK
- KMID: 2416069
- Nat Prod Sci.
- 2018 Jun;24(2):99-102.
- doi: 10.20307/nps.2018.24.2.99
This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at... -
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- Morphologic Comparison of Peripheral Nerves in Adipocyte Tissue from db/db Diabetic versus Normal Mice
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Lee KA, Lee NY, Park TS, Jin HY
- KMID: 2418710
- Diabetes Metab J.
- 2018 Apr;42(2):169-172.
- doi: 10.4093/dmj.2018.42.2.169
Present study investigated the morphologic changes of autonomic nerves in the adipose tissue in diabetic animal model. Male obese type 2 diabetic db/db mice and age matched non-diabetic db/m control... -
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- The Effect of Recombinant Tyrosine Hydroxylase Expression on the Neurogenic Differentiation Potency of Mesenchymal Stem Cells
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Turac G, Duruksu G, Karaoz E
- KMID: 2413271
- Neurospine.
- 2018 Mar;15(1):42-53.
- doi: 10.14245/ns.1836010.005
OBJECTIVE: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells... -
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- Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder
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Lee B, Shim I, Lee H, Hahm DH
- KMID: 2410108
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):183-192.
- doi: 10.4196/kjpp.2018.22.2.183
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear... -
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- Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition
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Wang X, Ma S, Wu H, Shen X, Xu S, Guo X, Bolick ML, Wu S, Wang F
- KMID: 2440027
- Exp Mol Med.
- 2018 Feb;50(2):e445.
- doi: 10.1038/emm.2017.271
Our previous works disclosed the contributing role of macrophage migration inhibitory factor (MIF) and dopaminergic inhibition by lysine dimethyltransferase G9a/Glp complex in peripheral nerve injury-induced hypersensitivity. We herein propose that... -
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- MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation
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Lee S, Oh ST, Jeong HJ, Pak SC, Park HJ, Kim J, Cho HS, Jeon S
- KMID: 2395257
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):625-632.
- doi: 10.4196/kjpp.2017.21.6.625
Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this... -
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- A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities
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Jang Y, Lee MJ, Han J, Kim SJ, Ryu I, Ju X, Ryu MJ, Chung W, Oh E, Kweon GR, Heo JY
- KMID: 2376578
- Exp Neurobiol.
- 2017 Apr;26(2):104-112.
- doi: 10.5607/en.2017.26.2.104
Movement defects in obesity are associated with peripheral muscle defects, arthritis, and dysfunction of motor control by the brain. Although movement functionality is negatively correlated with obesity, the brain regions... -
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- Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension
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Lee YH, Kim YG, Moon JY, Kim JS, Jeong KH, Lee TW, Ihm CG, Lee SH
- KMID: 2369607
- Electrolyte Blood Press.
- 2016 Dec;14(2):21-26.
- doi: 10.5049/EBP.2016.14.2.21
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the... -
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- Clinical Significance of Tyrosine Hydroxylase mRNA Transcripts in Peripheral Blood at Diagnosis in Patients with Neuroblastoma
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Lee NH, Son MH, Choi YB, Yi E, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2356242
- Cancer Res Treat.
- 2016 Oct;48(4):1399-1407.
- doi: 10.4143/crt.2015.481
PURPOSE: The purpose of this study is to investigate the clinical significance of tyrosine hydroxylase (TH) expression in peripheral blood (PB) at diagnosis in patients with neuroblastoma. MATERIALS AND METHODS: TH... -
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- Effects of Gypenosides on Dopaminergic Neuronal Cell Death in 6-Hydroxydopamine-lesioned Rat Model of Parkinson's Disease with Long-term L-DOPA Treatment
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Shin KS, Zhao TT, Park HJ, Kim KS, Choi HS, Lee MK
- KMID: 2355144
- Nat Prod Sci.
- 2016 Sep;22(3):187-192.
- doi: 10.20307/nps.2016.22.3.187
The goal of this study was to determine whether gypenosides (GPS) exert protective effects against dopaminergic neuronal cell death in a 6-hydroxydopamine (OHDA)-lesioned rat model of Parkinson's disease (PD) with... -
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