J Korean Med Sci.  2017 Feb;32(2):272-277. 10.3346/jkms.2017.32.2.272.

The Curves Exercise Suppresses Endotoxemia in Korean Women with Obesity

• Jin SA
• Kim SK
• Seo HJ
• Kim M
• Ahn KT
• Kim JH
• Park JH
• Lee JH
• Choi SW
• Jeong JO

• KMID: 2364171
• DOI: http://doi.org/10.3346/jkms.2017.32.2.272

Abstract

Obesity and metabolic syndrome is a worldwide pandemic and associated with high cardiovascular risk. Metabolic endotoxemia (ME) is thought to be an underlying molecular mechanism. It triggers toll-like receptor 4-mediated inflammatory adipokines and causes a chronic low grade inflammatory status, which results in cardiovascular risk increase. Exercise is the best nonpharmacological treatment to improve prognosis. In this study, we examined the circulating endotoxin level in Korean obese women and investigated effects of exercise on it. Women over body mass index (BMI) 25 kg/m2 participated in a resistance training exercise, Curves. At baseline and after 12 weeks exercise, tests including blood samples were taken. In Korean obese women, the fasting endotoxin was 1.45 ± 0.11 EU/mL. Ingestion of a high calorie meal led to a peak level after 2 hours (postprandial 2 hours [PP2]) and a significant rise over the 4 hours (postprandial 4 hours [PP4]) in it (1.78 ± 0.15 and 1.75 ± 0.14 EU/mL for PP2 and PP4, P < 0.05 vs. fasting). After exercise, BMI and hip circumference were reduced significantly. The total cholesterol (TC) at fasting, PP2 and PP4 were decreased significantly. All levels of circulating endotoxin at fasting, PP2 and PP4 showed reduction. But, the peak change was only significant (baseline vs. 12 weeks for PP2; 1.78 ± 0.15 vs. 1.48 ± 0.06 EU/mL, P < 0.05). We report the circulating endotoxin level in Korean obese women for the first time. Also, we establish that energy intake leads to endotoxemia and exercise suppresses the peak endotoxemia after meal. It suggests an impact for a better prognosis in obese women who follow regular exercise.

Keyword

Endotoxemia; Endotoxins; Exercise; Gut Microbiota; Lipopolysaccharides; Obesity

MeSH Terms

Adipokines
Body Mass Index
Cholesterol
Eating
Endotoxemia*
Endotoxins
Energy Intake
Fasting
Female
Gastrointestinal Microbiome
Hip
Humans
Lipopolysaccharides
Meals
Obesity*
Pandemics
Prognosis
Resistance Training
Toll-Like Receptors
Adipokines
Cholesterol
Endotoxins
Lipopolysaccharides
Toll-Like Receptors

Figure

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  Fig. 1 The postprandial changes of glucose, endotoxin, and lipid profiles before and after exercise. PP0 = postprandial 0 hours, PP2 = postprandial 2 hours, PP4 = postprandial 4 hours, LDL = low-density lipoprotein, HDL = high-density lipoprotein. *P < 0.01; †P < 0.05.

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