Gut Liver.  2016 Mar;10(2):220-227. 10.5009/gnl14310.

Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms

• Kim YB
• Lee SY
• Kim JH
• Sung IK
• Park HS
• Shim CS
• Han HS

• KMID: 2363966
• DOI: http://doi.org/10.5009/gnl14310

Abstract

BACKGROUND/AIMS
Microsatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and colorectal neoplasms.
METHODS
Consecutive patients who underwent both esophagogastroduodenoscopy and colonoscopy before the resection of gastric or colorectal cancers were included. MSI was analyzed using two mononucleotide and three dinucleotide markers.
RESULTS
In total, 434 gastric cancers (372 microsatellite stability [MSS], 21 low incidence of MSI [MSI-L], and 41 high incidence of MSI [MSI-H]) and 162 colorectal cancers (138 MSS, 9 MSI-L, and 15 MSI-H) were included. Patients with MSI gastric cancer had a higher prevalence of synchronous colorectal cancer, colorectal adenoma, and gastric adenoma than those with MSS gastric cancers (4.8% vs 0.5%, p=0.023; 11.3% vs 3.2%, p=0.011; 3.2% vs 1.2%, p=0.00, respectively). The prevalence of synchronous colorectal adenomas was highest in MSI-L gastric cancers (19.0%), compared with MSI-H (7.3%) or MSS (3.2%) gastric cancers (p=0.002). In addition, there were no significant differences in the prevalence rates of synchronous colorectal adenoma among the MSI-H (13.3%), MSI-L (11.1%), and MSS (12.3%) colorectal cancers (p=0.987).
CONCLUSIONS
The presence of MSI in gastric cancer may be a predictor of synchronous gastric and colorectal neoplasms, whereas MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.

Keyword

Microsatellite instability; Stomach neoplasms; Colorectal neoplasms; Adenoma

MeSH Terms

Adenoma/*genetics/surgery
Aged
Colonoscopy
Colorectal Neoplasms/*genetics/surgery
Endoscopy, Digestive System
Female
Humans
Male
*Microsatellite Instability
Middle Aged
Neoplasms, Multiple Primary/*genetics/surgery
Predictive Value of Tests
Stomach Neoplasms/*genetics/surgery