Korean J Med.  2010 Aug;79(2):113-118.

Understanding of molecular pathogenesis and genetic markers in colorectal cancer

Affiliations
  • 1Department of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Colorectal cancers results from the progressive accumulation of genetic and epigenetic alterations that lead to cellular transformation and tumor progression. Genomic instability, including chromosomal translocations and microsatellite instability, plays a role in acquisition of enough mutations for malignant transformation. In addition, epigenetic silencing is an important mechanism in the evolution of a subgroup of colorectal cancers. These genetic and epigenetic changes causes activation of oncogene pathway (APC, KRAS) and inactivation of tumor-suppressor pathway (p53, TGF-beta). Recent advance in colorectal carcinogenensis leads to development of molecular markers for early detection and predictive and prognostic markers.

Keyword

Colorectal cancer; Genetic instability; Epigenetic change; Biomarker

MeSH Terms

Colorectal Neoplasms
Epigenomics
Genetic Markers
Genomic Instability
Microsatellite Instability
Oncogenes
Translocation, Genetic
Genetic Markers
Full Text Links
  • KJM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr