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Clinical Application of Genetics in Management of Colorectal Cancer

Kim ER, Kim YH

The extensive study of genetic alterations in colorectal cancer (CRC) has led to molecular diagnostics playing an increasingly important role in CRC diagnosis and treatment. Currently, it is believed that...
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Understanding of molecular pathogenesis and genetic markers in colorectal cancer

Kim YH

  • KMID: 2259110
  • Korean J Med.
  • 2010 Aug;79(2):113-118.
Colorectal cancers results from the progressive accumulation of genetic and epigenetic alterations that lead to cellular transformation and tumor progression. Genomic instability, including chromosomal translocations and microsatellite instability, plays a...
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Genetic Instability in Gastric Epithelial Neoplasias Categorized by the Revised Vienna Classification

Chung WC, Jung SH, Lee KM, Paik CN, Kwak JW, Jung JH, Yoo JY, Lee MK, Chung IS

  • KMID: 2284183
  • Gut Liver.
  • 2010 Jun;4(2):179-185.
BACKGROUND/AIMS: The aim of this study was to determine the structural chromosomal aberrations, such as loss of heterozygosity (LOH) and microsatellite instability (MSI), at multiple tumor suppressor gene loci in...
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Genetic Instability and Mutations of Mismatch Repair (MMR) and p53 Gene in Colorectal Cancers with Multiple Polyps and Sporadic Colorectal Cancers

Chun SW, Chang SK

  • KMID: 2334284
  • J Korean Soc Coloproctol.
  • 2002 Dec;18(6):353-362.
PURPOSE: General conceptions of carcinogenic mechanisms by recent reports are ras-p53 gene pathway in sporadic colorectal cancers (SCC), MMR gene pathway in hereditary nonpolyposis colorectal cancer (HNPCC) and APC gene...
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