- Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis
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Yin H, Wang S, Gu C
- KMID: 2471339
- Ann Dermatol.
- 2020 Apr;32(2):130-140.
- doi: 10.5021/ad.2020.32.2.130
BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,... -
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- Immunotherapy for Non-small Cell Lung Cancer: Current Landscape and Future Perspectives
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Lim SM, Hong MH, Kim HR
- KMID: 2471050
- Immune Netw.
- 2020 Feb;20(1):e10.
- doi: 10.4110/in.2020.20.e10
Immune checkpoint inhibitors (ICIs) have shown remarkable benefit in the treatment of patients with non-small-cell lung cancer (NSCLC) and have emerged as an effective treatment option even in the first-line... -
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- Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression
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Seo D, Kim D, Kim W
- KMID: 2468862
- Genomics Inform.
- 2019 Dec;17(4):e36.
- doi: 10.5808/GI.2019.17.4.e36
The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence... -
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- Asiatic Acid Induces Apoptosis and Autophagy and Reduces MiR-17 and MiR-21 Expression in Pancreatic Cancer Cell Lines
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Jo YG, Kim M, Shin H, Lee KY, Lee EJ
- KMID: 2468062
- Nat Prod Sci.
- 2019 Dec;25(4):298-303.
- doi: 10.20307/nps.2019.25.4.298
This study investigated the cytotoxic effects and mechanism of action of asiatic acid in pancreatic cancer cell lines. First, we confirmed the cell viability of MIA PaCa-2 and PANC-1 cells... -
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- Sonic Hedgehog Pathway as the Prognostic Marker in Patients with Extensive Stage Small Cell Lung Cancer
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Lim S, Lim SM, Kim MJ, Park SY, Kim JH
- KMID: 2459142
- Yonsei Med J.
- 2019 Oct;60(10):898-904.
- doi: 10.3349/ymj.2019.60.10.898
PURPOSE: Sonic hedgehog (Shh) signaling pathway is known to play a crucial role in carcinogenesis in various malignancies, including lung cancer regarding tumorigenesis, angiogenesis, and cellular differentiation. The aim of... -
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- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells
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Kim D, Lim JW, Kim H
- KMID: 2468801
- J Cancer Prev.
- 2019 Sep;24(3):192-196.
- doi: 10.15430/JCP.2019.24.3.192
BACKGROUND: Helicobacter pylori infection is a major risk factor in the development of gastric cancer. H. pylori infection of gastric epithelial cells increases the levels of reactive oxygen species (ROS),... -
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- Cutaneous Angiosarcoma of the Foot Accompanied by Multiple Myeloma: The First Case Report
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Jo JW, Shin YB, Kwon CI, Kim CY
- KMID: 2457693
- Korean J Dermatol.
- 2019 Aug;57(7):399-402.
Although the exact etiology of cutaneous angiosarcoma remains unclear, MYC gene amplification has been recently discovered as a new pathogenesis. MYC is a proto-oncogene, and aberration of MYC signaling in... -
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- KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer
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Zhou J, Chen WR, Yang LC, Wang J, Sun JY, Zhang WW, He ZY, Wu SG
- KMID: 2454312
- Cancer Res Treat.
- 2019 Jul;51(3):1207-1221.
- doi: 10.4143/crt.2018.460
PURPOSE: The study aimed to search and identify genes that were differentially expressed in breast cancer, and their roles in cancer growth and progression. MATERIALS AND METHODS: The Gene Expression Omnibus... -
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- Usefulness of Chromosomal Microarray in Hematologic Malignancies: A Case of Aggressive NK-cell Leukemia with 1q Abnormality
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Chung YN, Kim HN, Lee SR, Sung HJ, Nam MH
- KMID: 2450847
- Lab Med Online.
- 2019 Jul;9(3):189-193.
- doi: 10.3343/lmo.2019.9.3.189
A variety of clonal cytogenetic abnormalities have been reported in aggressive natural killer (NK)-cell lymphoma and leukemia. Recent chromosomal microarray studies have shown both gain and loss of 1q and... -
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- The Roles of miRNAs in Medulloblastoma: A Systematic Review
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Mollashahi B, Aghamaleki FS, Movafagh A
- KMID: 2454668
- J Cancer Prev.
- 2019 Jun;24(2):79-90.
- doi: 10.15430/JCP.2019.24.2.79
Medulloblastoma is considered one of the most threatening malignant brain tumors with an extremely high mortality rate in children. In the medulloblastoma, there are several genes and mutations found to... -
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- Prominent Inflammatory Features of Monocytes/Macrophages in Acute Calcium Pyrophosphate Crystal Arthritis: a Comparison with Acute Gouty Arthritis
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Jeong JH, Jung JH, Lee JS, Oh JS, Kim YG, Lee CK, Yoo B, Hong S
- KMID: 2450206
- Immune Netw.
- 2019 Jun;19(3):e21.
- doi: 10.4110/in.2019.19.e21
Calcium pyrophosphate (CPP) crystals can present as acute inflammatory arthritis which is known as an acute CPP crystal arthritis. Although monocytes/macrophages have been shown to play a role in the... -
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- The Long Noncoding RNA NEAT1 Targets miR-34a-5p and Drives Nasopharyngeal Carcinoma Progression via Wnt/β-Catenin Signaling
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Ji Y, Wang M, Li X, Cui F
- KMID: 2450188
- Yonsei Med J.
- 2019 Apr;60(4):336-345.
- doi: 10.3349/ymj.2019.60.4.336
PURPOSE: Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been deemed an oncogene in many human cancers. However, the underlying mechanism of NEAT1 in nasopharyngeal carcinoma (NPC) progression... -
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- Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1
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Chen L, Zhong J, Liu JH, Liao DF, Shen YY, Zhong XL, Xiao X, Ding WJ, Peng XD, Xiong W, Zu XY
- KMID: 2441848
- J Breast Cancer.
- 2019 Mar;22(1):15-28.
- doi: 10.4048/jbc.2019.22.e11
PURPOSE: Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study... -
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- Mouse Models as a Tool for Understanding Progression in Braf(V600E)-Driven Thyroid Cancers
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Landa I, Knauf JA
- KMID: 2441674
- Endocrinol Metab.
- 2019 Mar;34(1):11-22.
- doi: 10.3803/EnM.2019.34.1.11
The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have... -
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- Roles of Oncogenic Long Non-coding RNAs in Cancer Development
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Do H, Kim W
- KMID: 2439208
- Genomics Inform.
- 2018 Dec;16(4):e18.
- doi: 10.5808/GI.2018.16.4.e18
Long non-coding RNAs (lncRNAs) are classified as RNAs that are longer than 200 nucleotides and cannot be translated into protein. Several studies have demonstrated that lncRNAs are directly or indirectly... -
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- Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer
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Kim K, Castro EJ, Shim H, Advincula , Kim YW
- KMID: 2434373
- Ann Coloproctol.
- 2018 Dec;34(6):280-285.
- doi: 10.3393/ac.2018.12.17
For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction... -
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- Comprehensive MicroRNAome Analysis of the Relationship Between Alzheimer Disease and Cancer in PSEN Double-Knockout Mice
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Ham S, Kim TK, Ryu J, Kim YS, Tang YP, Im HI
- KMID: 2431864
- Int Neurourol J.
- 2018 Dec;22(4):237-245.
- doi: 10.5213/inj.1836274.137
PURPOSE: Presenilins are functionally important components of γ-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer... -
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- Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma
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Lee M, Ko H, Yun M
- KMID: 2426327
- Yonsei Med J.
- 2018 Dec;59(10):1143-1149.
- doi: 10.3349/ymj.2018.59.10.1143
Various molecular targeted therapies and diagnostic modalities have been developed for the treatment of hepatocellular carcinoma (HCC); however, HCC still remains a difficult malignancy to cure. Recently, the focus has... -
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- The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts
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Kim EC, Lee DY, Lee MH, Lee HJ, Kim KH, Leesungbok R, Ahn SJ, Park SJ, Yoon JH, Jee YJ, Lee SC, Lee SW
- KMID: 2422675
- Tissue Eng Regen Med.
- 2018 Oct;15(5):615-627.
- doi: 10.1007/s13770-018-0153-7
BACKGROUND: We aimed to determine the effect of fibronectin (FN)-immobilized microgrooved titanium (Ti) on human gingival fibroblast proliferation, gene expression and protein expression. METHODS: Photolithography was used to fabricate the microgrooved... -
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- PIM Kinase as an Executional Target in Cancer
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Zhang X, Song M, Kundu JK, Lee MH, Liu ZZ
- KMID: 2425313
- J Cancer Prev.
- 2018 Sep;23(3):109-116.
- doi: 10.15430/JCP.2018.23.3.109
PIM (proviral integration site for moloney murine leukemia virus) kinase plays a key role as an oncogene in various cancers including myeloma, leukemia, prostate and breast cancers. The aberrant expression... -
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