Expression of Oncogenes in Gastric Cancer: As a Correlation between Oncogene Expression and Prognosis

Yoon, Chong Mann; Rew, Jong Sun; Choi, Sung Kyu; Park, Chang Soo; Koo, Cheol; Rhew, Do Hyun

Abstract

BACKGROUND/AIMS: Gastric cancer is the most frequent and occupies the leading cause of death from cancer in Korea. Expression of oncogenes and tumor suppressor genes were studied widely according to the tumor invasion, lymph node metastasis, distant metastasis and stages. But these studies were rarely investigated according to the mean survival duration the 5-year survival rate.
METHODS
A retrospective analysis of 95 cases of gastric cancer was performed to evaluate the prognostic significance of clinicopathologic features such as histologic type, depth of invasion, status of lymph node metastasis, distant metastasis, stages, mean survival duration and survival rate according to the expression of c-erb B2, c-H-ras, p53 gene product by imrnunohistochemical staining.
RESULTS
The mean survival duration is 51.0 months. Expression of c-erb B2 is 66.3% (63/95), c-H-ras 51.6%(49/95) and p53 37.9%(36/95). c-erb B2 expression is closely correlated to the depth of invasion, c-H-ras is closely correlated to the depth of invasion and lymph node metastasis but p53 is not significantly correlated to the depth of invasion, lymph node metastasis and distant metastasis. Expression of c-erb B2, c-H-ras, p53 is not correlated to mean survival duration and 5-year survival rate.
CONCLUSIONS
Expression of oncogenes has no significance in prognosis of gastric cancer.