Endocrinol Metab.  2013 Dec;28(4):245-254. 10.3803/EnM.2013.28.4.245.

The Molecular Pathogenesis of Pituitary Adenomas: An Update

• Jiang X
• Zhang X

• KMID: 2169301
• DOI: http://doi.org/10.3803/EnM.2013.28.4.245

Abstract

Pituitary tumors represent the most common intracranial neoplasms accompanying serious morbidity through mass effects and inappropriate secretion of pituitary hormones. Understanding the etiology of pituitary tumorigenesis will facilitate the development of satisfactory treatment for pituitary adenomas. Although the pathogenesis of pituitary adenomas is largely unknown, considerable evidence indicates that the pituitary tumorigenesis is a complex process involving multiple factors, including genetic and epigenetic changes. This review summarized the recent progress in the study of pituitary tumorigenesis, focusing on the role of tumor suppressor genes, oncogenes and microRNAs.

Keyword

Pituitary neoplasms; Oncogenes; Tumor suppressors; Cell cycle; MicroRNAs

MeSH Terms

Brain Neoplasms
Cell Cycle
Cell Transformation, Neoplastic
Epigenomics
Genes, Tumor Suppressor
MicroRNAs
Oncogenes
Pituitary Hormones
Pituitary Neoplasms*
MicroRNAs
Pituitary Hormones