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Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas

Kim YH, Kim JH

BACKGROUND: Invasive nonfunctioning pituitary adenomas (NFPAs) remain challenging due to their high complication rate and poor prognosis. We aimed to identify the distinctive molecular signatures of invasive NFPAs, compared with...
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Clinical Usefulness of Trasseptal Transsphenoidal Approach for Pituitary Tumors with Septal Cartilage Removal and Replacement via Modified Killian Incision: Review of 42 Cases

Kim SY, Yang BW, Lee YW, Lee KC

BACKGROUND AND OBJECTIVES: The conventional transseptal transsphenoidal approach can inhibit visualization of the surgical field and may change the shape of external nose. We used the transseptal transsphenoidal technique to...
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MicroRNA-186 targets SKP2 to induce p27(Kip1)-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation

He Z, Chen L, Wang Q, Yin C, Hu J, Hu X, Fei F, Tang J

Pituitary tumors are usually benign but can occasionally exhibit hormonal and proliferative behaviors. Dysregulation of the G1/S restriction point largely contributes to the over-proliferation of pituitary tumor cells. F-box protein...
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Utilization of the Nasoseptal Flap for Repair of Cerebrospinal Fluid Leak after Endoscopic Endonasal Approach for Resection of Pituitary Tumors

Kessler RA, Garzon-Muvdi T, Kim E, Ramanathan M, Lim M

BACKGROUND: One of the most frequent complications after endoscopic endonasal approach (EEA) for resection of pituitary tumors is cerebrospinal fluid (CSF) leaks. With the introduction of the pedicled nasoseptal flap,...
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Growth Pattern and Prognostic Factors of Untreated Nonfunctioning Pituitary Adenomas

Hwang K, Kwon T, Park J, Joo JD, Han JH, Oh CW, Kim CY

OBJECTIVE: Pituitary adenomas (PAs) are often detected as incidental findings. However, the natural history remains unclear. The objective of this study was to evaluate the natural history and growth pattern...
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LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma

Hwang M, Han MH, Park HH, Choi H, Lee KY, Lee YJ, Kim JM, Cheong JH, Ryu JI, Min KW, Oh YH, Ko Y, Koh SH

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and...
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Metastasis of Hepatocellular Carcinoma to Pituitary Adenoma: A Case Report

Hong YS, Cho YS, Kim CG, Lee MJ

Metastasis to the pituitary gland is unusual, and metastasis to pituitary adenoma is extremely rare. We report here on a case of hepatocellular carcinoma metastasizing to a pituitary adenoma with...
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Factors Influencing Visual Field Recovery after Transsphenoidal Resection of a Pituitary Adenoma

Lee DK, Sung MS, Park SW

PURPOSE: This study aimed to analyze the factors influencing visual field recovery after transsphenoidal approach-tumor resection (TSA-TR) in pituitary adenoma patients with visual field defects (VFDs). METHODS: We retrospectively evaluated 102...
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Group B Streptococcus Meningitis Presenting as the Initial Symptom of a Recurrent Pituitary Adenoma

Kang KW, Baek BH, Kim SH, Kim HS, Nam TS, Lim SC, Kim MK

No abstract available.
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A rare case of multiple pituitary adenomas in an adolescent Cushing disease presenting as a vertebral compression fracture

Song JY, Mun SJ, Sung SK, Hwang JY, Baik SK, Kim JY, Cheon CK, Kim SY, Kim YM

Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain,...
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Recent Progress in the Medical Therapy of Pituitary Tumors

Langlois F, McCartney , Fleseriu M

Management of pituitary tumors is multidisciplinary, with medical therapy playing an increasingly important role. With the exception of prolactin-secreting tumors, surgery is still considered the first-line treatment for the majority...
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Pituitary Epithelioid Osteosarcoma after Gamma-knife Surgery of a Pituitary Adenoma

Park SY, Kim YJ, Lee EJ, Choi JS, Kim JH, Jin SM, Hur KY

With the increasing use of stereotactic radiosurgery, recent reports have suggested that stereotactic radiosurgery may induce secondary malignancies. While the risk of secondary malignancy after conventional radiotherapy is well known,...
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A Case of Coincidental Intrasellar Chordoma and Pituitary Adenoma

Park S, Kim HS, Park KS, Nam TK, Park YS, Kwon JT, Kim KT

Although chordomas are midline tumors, primarily intrasellar chordomas are extremely rare. In this report, the authors describe the case of a 68-year-old female with partial abducens nerve palsy in the...
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Long-term outcomes of surgery and radiotherapy for secreting and non-secreting pituitary adenoma

Kim MY, Kim JH, Oh YK, Kim E

PURPOSE: To investigate treatment outcome and long term complication after surgery and radiotherapy (RT) for pituitary adenoma. MATERIALS AND METHODS: From 1990 to 2009, 73 patients with surgery and RT for...
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Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma

Lee MH, Lee JH, Seol HJ, Lee JI, Kim JH, Kong DS, Nam DH

BACKGROUND: Non-functioning pituitary adenomas (NFPA) are clinically challenging because they present at a late stage with local mass effects or hypopituitarism. Surgery for non-functioning pituitary adenoma requires a special strategic...
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Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma

Zhou Y, Zhu Y, Wang W, Xing B

Few preoperative extrapontine myelinolysis (EPM) cases with pituitary adenoma have been reported. No such case had long follow-up to see the outcome of EPM. We reported a 38-year-old man complaining...
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A patient with Cushing disease lateralizing a pituitary adenoma by inferior petrosal sinus sampling using desmopressin: a case report

Lim JH, Kim SJ, Jung MK, Kim KE, Kwon AR, Chae HW, Kim DH, Kim HS

A 14-year-old girl was referred for evaluation of the etiology of Cushing syndrome. During the previous 2 years, she had experienced weight gain, secondary amenorrhea, growth retardation, and back pain....
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A Primary Sellar Neuroblastoma Mimicking a Pituitary Adenoma: A Case Report

Kim DG, Heo YJ, Kim EK, Baek JW, Jeong HW, Jung HS

Intracranial neuroblastomas are uncommon malignant tumors that usually arise in the supratentorial parenchymal or paraventricular location. A primary neuroblastoma arising in the sella turcica is extremely rare. We report a...
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Parasellar Extension Grades and Surgical Extent in Endoscopic Endonasal Transsphenoidal Surgery for Pituitary Adenomas : A Single Surgeon's Consecutive Series with the Aspects of Reliability and Clinical Validity

Lee SH, Park JS, Lee S, Kim SW, Hong YK

OBJECTIVE: The inter-rater reliability of the modified Knosp's classification was measured before the analysis. The clinical validity of the parasellar extension grading system was evaluated by investigating the extents of...
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The Predictive Value of Pathologic Features in Pituitary Adenoma and Correlation with Pituitary Adenoma Recurrence

Kim JS, Lee YS, Jung MJ, Hong YK

BACKGROUND: The 2004 World Health Organization classification introduced atypical pituitary adenoma (aPA), which was equivocally defined as invasion with increased mitotic activity that had a Ki-67 labeling index (LI) greater...
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