J Gastric Cancer.  2010 Dec;10(4):149-154.

Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients

• Kim SH
• Ahn BK
• Nam YS
• Pyo JY
• Oh YH
• Lee KH

Abstract

PURPOSE
Replication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the development of multiple gastric cancers in sporadic gastric cancer patients has not been defined. This study was performed to reveal the association between the clinicopathologic features and MSI in sporadic gastric cancers.
MATERIALS AND METHODS
Between July 2004 and March 2009, the clinicopathologic characteristics, including MSI status, were evaluated in 128 consecutive patients with sporadic gastric cancers. None of the patients had hereditary non-polyposis colorectal cancer of familial gastric cancer. The markers that were recommended by the NCI to determine the MSI status for colorectal cancers were used.
RESULTS
MSI-H cancers were found in 10.9% of the patients (14/128). Synchronous gastric cancers were shown in 4 patients (3.1%). Synchronous cancers were found in 2 of 14 patients with MSI-H gastric cancer (14.3%) and 2 of 114 patients with MSS gastric cancer (1.8%; P=0.059, Fisher's exact test). Among the patients with synchronous cancer 50% (2/4) had MSI-H cancer, but 9.7% of the patients (12/124) without synchronous cancer had MSI-H cancer. MSI-H (RR, 24.7; 95% CI, 1.5~398.9; P=0.024) was related with to synchronous gastric cancer, but age, gender, family history, histologic type, location, gross morphology, size, and stage were not related to synchronous gastric cancer.
CONCLUSIONS
MSI is associated with the intestinal-type gastric cancer and the presence of multiple gastric cancers in patients with sporadic gastric cancer. Special attention to the presence of synchronous and the development of metachronous multiple cancer in patients with MSI-H gastric cancer is needed.

Keyword

Microsatellite instability; Stomach neoplasms; Synchronous gastric cancer

MeSH Terms

Colorectal Neoplasms
Humans
Microsatellite Instability
Microsatellite Repeats
Stomach Neoplasms
Succinimides
Succinimides

Figure

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  Fig. 1 An example of PCR analysis of microsatellite instability. Tumor DNA shows alterations of allele lengths in BAT25, BAT26, D5S346, D2S123, and D17S250. ▾ = arrow heads indicate microsatellite instability. Microsatellite instability is associated with the clinicopathologic features of gastric cancer in sporadic gastric cancer patients.

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