Ewha Med J.  2004 Sep;27(2):101-105. 10.12771/emj.2004.27.2.101.

Correlation MSI Status and Other Prognostic Factors in Sporadic Colorectal Cancer

• Lee SN

• KMID: 1964092
• DOI: http://doi.org/10.12771/emj.2004.27.2.101

Abstract

OBJECTIVES
The purpose of this study was to evaluate MSI status in sporadic colorectal cancer and to correlate it with clinicopathologic variables.
METHODS
Total 45 cases of surgically resected colorectal cancers retrospectively were reviewed about clinicopathologic findings and analyzed for micro satellite instability.
RESULTS
The microsatellite instability (MSI) was found in 5 of 45 cases (11.1%) . A significant association was found between MSI+ tumors and location in the right colon (40%), and high histological grade (100.0%), and mucinous phenotype (33.3%). There was no significant difference for age, sex, growth pattern, lymph node metastases, vessel invasion, or Duke's stage.
CONCLUSION
These data indicate that MSI frequently occur in colorectal cancers of the right side and in tumors with poorly differentiated or mucinous histology.

Keyword

Colorectal cancer; Microsatellite instability; Clinicopathologic variables

MeSH Terms

Colon
Colorectal Neoplasms*
Lymph Nodes
Microsatellite Instability
Mucins
Neoplasm Metastasis
Phenotype
Retrospective Studies
Mucins