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Biodistribution of 99mTc Labeled Integrin Antagonist

Jang BS, Park SH, Shin IS, Maeng JS, Paik CH

  • KMID: 2317812
  • Toxicol Res.
  • 2013 Mar;29(1):21-25.
The selective targeting of an integrin alphavbeta3 receptor using radioligands may enable the assessment of angiogenesis and integrin alphavbeta3 receptor status in tumors. The aim of this research was to...
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Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes

Kim JY, Shin NR, Kim A, Lee HJ, Park WY, Kim JY, Lee CH, Huh GY, Park DY

  • KMID: 1837568
  • Korean J Pathol.
  • 2013 Feb;47(1):28-35.
BACKGROUND: Gastric cancers with microsatellite instabilities (MSI) have been reported to be associated with favorable prognosis. However, the significance of the effect of MSI on the clinicopathological features, as well...
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Radiotherapy Response in Microsatellite Instability Related Rectal Cancer

Shin JS, Tut TG, Yang T, Lee CS

  • KMID: 1837564
  • Korean J Pathol.
  • 2013 Feb;47(1):1-8.
Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no...
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In Vitro and In Vivo Imaging of Prostate Cancer Angiogenesis Using Anti-Vascular Endothelial Growth Factor Receptor 2 Antibody-Conjugated Quantum Dot

Kwon H, Lee J, Song R, Hwang SI, Lee J, Kim YH, Lee HJ

OBJECTIVE: Authors aimed to determine the targeting ability of vascular endothelial growth factor receptor 2 (VEGFR2)-conjugated quantum dots (QDs) in vitro, and apply it for a xenograft prostate cancer mouse...
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Clinico-pathologic Parameters for Prediction of Microsatellite Instability in Colorectal Cancer

Jung SB, Lee HI, Oh HK, Shin IH, Jeon CH

  • KMID: 1972726
  • Cancer Res Treat.
  • 2012 Sep;44(3):179-186.
PURPOSE: Although the incidence of microsatellite instability (MSI) accounts for 10-15% of cases of colorectal cancer, its clinical application for all colorectal cancers has widened. We attempted to identify clinical...
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Markers for Screening Lynch Syndrome Are Reliable and Useful for Identifying the Specimen Mislabeling

Byeon SJ, Choi J, Nam KH, Jang BG, Lee HE, Kim MA, Kim WH

  • KMID: 2011980
  • Korean J Pathol.
  • 2012 Apr;46(2):131-136.
BACKGROUND: During specimen processing in surgical pathology laboratories, specimen-related adverse events (SRAEs), such as mislabeling and specimen mixed-up might occur. In these situations, molecular techniques using short tandem repeat (STR)...
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Association of Estrogen Receptor 2(ESR 2) Gene Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Spine

Kim KT, Lee SH, Kwack YH, Son ES, Park KJ, Kim DH

STUDY DESIGN: Genetic screening of the estrogen receptor 2 (ESR2) genes in patients with ossification of the posterior longitudinal ligament (OPLL). OBJECTIVE: We studied the relationships between ESR2 gene polymorphisms and...
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Qualitative and quantitative evaluation of root injury risk potentially burdening insertion of miniscrew implants

Antoszewska J, Trzesniewska P, Kawala B, Ludwig B, Park HS

OBJECTIVE: Microscrew implants (MSIs) offer many advantages, but some complications are known to occur during their insertion. One of the most commonly reported complications is root injury. Our aim was...
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Molecular Biological Characteristics of Differentiated Early Gastric Cancer on the Basis of Mucin Expression

Shin N, Kim HY, Kim WK, Park MG, Kim KB, Shin DH, Choi KU, Kim JY, Lee CH, Huh GY, Sol MY, Park DY

  • KMID: 2277522
  • Korean J Pathol.
  • 2011 Feb;45(1):69-78.
BACKGROUND: It is clear that the biologic characteristics of gastric cancer are different on the basis of mucin phenotypes. However, there are unabated controversies on the exact biologic differences of...
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Regression of Hyperplastic Gastric Polyp after Helicobacter pylori Eradication

Lim SA, Yun JW, Yoon D, Choi W, Kim SH, Choe JW, Kim MN, Kang EJ, Park JJ, Joo MK, Lee BJ, Bak YT, Lee SW, Park JT

  • KMID: 1935712
  • Korean J Gastrointest Endosc.
  • 2011 Feb;42(2):74-82.
BACKGROUND/AIMS: Recent studies have suggested that the eradication of Helicobacter pylori (Hp) may lead to the regression of hyperplastic polyps (HPPs) in the stomach. We evaluated the sizes of HPPs...
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Mutation and Expression of DNA2 Gene in Gastric and Colorectal Carcinomas

Lee SH, Kim YR, Yoo NJ, Lee SH

  • KMID: 2277572
  • Korean J Pathol.
  • 2010 Aug;44(4):354-359.
BACKGROUND: Deregulation of DNA repair and replication are involved in cancer development. DNA2 is a nuclease/helicase that plays roles in DNA repair and replication. The aim of this study was...
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Overexpression of p53, Mutation of hMLH1 and Microsatellite Instability in Gastric Carcinomas: Clinicopathologic Implications and Prognosis

Kwon J, Lee JH, Jee YS, Park DJ, Kim HH, Lee HJ, Yang HK, Lee KU, Lee HS

PURPOSE: Mutated p53 is a tumor suppressor gene, hMLH1 is a mismatch repair gene, and hypermethylation of hMLH1 follows microsatellite instability (MSI). This research's aim is to investigate mutated p53,...
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Genetic Instability in Gastric Epithelial Neoplasias Categorized by the Revised Vienna Classification

Chung WC, Jung SH, Lee KM, Paik CN, Kwak JW, Jung JH, Yoo JY, Lee MK, Chung IS

  • KMID: 2284183
  • Gut Liver.
  • 2010 Jun;4(2):179-185.
BACKGROUND/AIMS: The aim of this study was to determine the structural chromosomal aberrations, such as loss of heterozygosity (LOH) and microsatellite instability (MSI), at multiple tumor suppressor gene loci in...
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Microsatellite Instability-low Colorectal Carcinomas: Are They Comparable with Microsatellite Stable Cancer?

Paek OJ, Oh SY, Kim YB, Suh KW

PURPOSE: Microsatellite instability-high (MSI-H) colorectal cancer (CRC) displays a well-described distinct phenotype, but the true biological significance of MSI-low (L) is still uncertain. To clarify the significance of this MSI-L,...
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Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients

Kim SH, Ahn BK, Nam YS, Pyo JY, Oh YH, Lee KH

  • KMID: 2372645
  • J Gastric Cancer.
  • 2010 Dec;10(4):149-154.
PURPOSE: Replication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the...
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Immunomodulatory effect of canine periodontal ligament stem cells on allogenic and xenogenic peripheral blood mononuclear cells

Kim HS, Kim KH, Kim SH, Kim YS, Koo KT, Kim TI, Seol YJ, Ku Y, Rhyu IC, Chung CP, Lee YM

PURPOSE: The aim of this study was to investigate the immunomodulatory effects of canine periodontal ligament stem cells on allogenic and xenogenic immune cells in vitro. METHODS: Mixed cell cultures consisting...
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Microsatellite Instability and p53 Gene Loss of Heterozygosity in Hepatocellular Carcinoma

Kim JS, Lim MS, Kim DJ, Kim JS, Kim KS, Kim HK, Cho SJ, Kwon MJ, Nam ES, Choi KC, Shin HS, Chae GB

  • KMID: 2083315
  • Korean J Hepatobiliary Pancreat Surg.
  • 2009 Sep;13(3):143-151.
PURPOSE: Hepatocellular carcinoma (HCC) shows various molecular and genetic alterations in its development and progression. Recently, microsatellite instability (MSI) and the loss of heterozygosity (LOH), have been postulated as useful...
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Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes

Lee HJ, Kim PH

We have recently shown that activin A, a member of TGF-beta superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the present study, we further characterized...
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Clinicopathological Characteristics of Colorectal Cancer according to Microsatellite Instability

Suk KT, Kim HS, Lee JH, Kim BR, Kim MY, Kim JW, Baik SK, Kwon SO, Chong Y, Cho MY

  • KMID: 2174113
  • Intest Res.
  • 2009 Jun;7(1):14-21.
BACKGROUND/AIMS: Microsatellite instability (MSI) is associated with mutations in the DNA mismatch repair system and accounts for 10-15% of all cases of sporadic colorectal cancer (CRC). However, the characteristics and...
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Loss of Heterozygosity on Chromosome 15q15 Near Thrombospondin-1 Gene in Breast Carcinomas

Kim J, Kim KM, Lee H, Lee K, Rhyu MG, Lee A, Kang SJ, Lee KY

  • KMID: 1979339
  • Korean J Pathol.
  • 2009 Jun;43(3):221-230.
BACKGROUND: Chromosome 15q15 near the thrombospondin-1 (THBS-1) gene may be associated with tumor progression and metastasis. To clarify the potential role of the15q15 region in progression of breast carcinoma, we...
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