Cancer Res Treat.  2006 Feb;38(1):25-29.

Characteristics of Synchronous Cancers in Gastric Cancer Patients

• Bae JS
• Lee JH
• Ryu KW
• Kim YW
• Bae JM

Abstract

PURPOSE
The primary objective of the current study was to investigate the characteristics of synchronous cancers in gastric cancer patients.
MATERIALS AND METHODS
We analyzed the 2,237 patients who were diagnosed between December 2000 and December 2003 with gastric cancer and synchronous cancers of organs other than the stomach.
RESULTS
73 (3.3%) of a total of 2,237 gastric cancer patients had synchronous primary cancers. Among these 73 patients, 71 had one synchronous cancer, and two patients had double synchronous cancers. Colorectal cancer (26 patients, 34.7%) was the most frequently encountered synchronous cancer, followed by cancer of the lung (16 patients, 21.3%), esophagus (13 patients, 17.2%), and liver (8 patients, 10.7%). Synchronous can-cers were detected with increased frequency in the elderly, in the patients with multiple gastric cancers, in the patients with differentiated gastric cancer, and in the patients with early gastric cancer, as determined on univariate analysis, but the differentiation of gastric cancers was the only risk factor for synchronous cancers on the multivariate analysis.
CONCLUSIONS
The differentiation of gastric cancer cells may be a risk factor for synchronous cancers in gastric cancer patients. Careful surveillance by the physician for synchronous cancer is warranted for the patients suffering from gastric cancer.

Keyword

Synchronous cancer; Stomach neoplasms; Colorectal neoplasms

MeSH Terms

Aged
Colorectal Neoplasms
Esophagus
Humans
Liver
Lung Neoplasms
Multivariate Analysis
Risk Factors
Stomach
Stomach Neoplasms*

Figure

• 

  Fig. 1 Location and number of synchronous cancers.

• 

  Fig. 2 Distribution of synchronous cancers according to the time of diagnosis of gastric cancer. *gastric cancer.

Reference

1. Shin HR, Jung KW, Won YJ, Park JG. 2002 Annual report of the Korea Central Cancer Registry: Based on registered data from 139 Hospitals. Cancer Res Treat. 2004; 36:103–114.

2. Akoh JA, Macintyre IM. Improving survival in gastric cancer. Review of 5-year survival rates in English language publications from 1970. Br J Surg. 1992; 79:193–199. PMID: 1555082.

3. Maehara Y, Kakeji Y, Oda S, Takahashi I, Akazawa K, Sugimachi K. Time trends of surgical treatment and the prognosis for Japanese patients with gastric cancer. Br J Cancer. 2000; 83:986–991. PMID: 10993643.

4. Lundegardh G, Hansson LE, Nyren O, Adami HO, Krusemo UB. The risk of gastrointestinal and other primary malignant disease following gastric cancer. Acta Oncol. 1991; 30:1–6. PMID: 2009177.

5. Hiyama T, Hanai A, Fujimoto I. Second primary cancer after diagnosis of stomach cancer in Osaka, Japan. Jpn J Cancer Res. 1991; 82:762–770. PMID: 1908843.

6. Ikeda Y, Saku M, Kawanaka H, Nonaka M, Yoshida K. Features of second primary cancer in patients with gastric cancer. Oncology. 2003; 65:113–117. PMID: 12931016.

7. Yoshino K, Asanuma F, Hanatani Y, Otani Y, Kumai K, Ishibiki K. Multiple primary cancers in the stomach and another organ: frequency and the effects on prognosis. Jpn J Clin Oncol. 1985; 15(suppl 1):183–190. PMID: 4009981.

8. Dinis-Ribeiro M, Lomba-Viana H, Silva R, Moreira-Dias L, Lomba-Viana R. Associated primary tumors in patients with gastric cancer. J Clin Gastroenterol. 2002; 34:533–535. PMID: 11960064.

9. Kato I, Kito T, NAkazato H, Tominaga S. Second malignancy in stomach cancer patients and its possible risk factors. Jpn J Clin Oncol. 1986; 16:373–381. PMID: 3795533.

10. Japanese Classification of Gastric Carcinoma - 2nd English edition. Gastric Cancer. 1998; 1:10–24. PMID: 11957040.

11. Ikeguchi M, Ohfuji S, Oka A, Tsujitani S, Maeda M, Kaibara N. Synchronous and metachronous primary malignancies in organs other than the stomach in patients with early gastric cancer. Hepatogastroenterology. 1995; 42:672–676. PMID: 8751233.

12. Ikeda Y, Saku M, Kishihara F, Maehara Y. Effective follow-up for recurrence or a second primary cancer in patients with early gastric cancer. Br J Surg. 2005; 92:235–239. PMID: 15609385.

13. Adachi Y, Yasuda K, Inomata M, Sato K, Shiraishi N, Kitano S. Pathology and prognosis of gastric carcinoma: well versus poorly differentiated. Cancer. 2000; 89:1418–1424. PMID: 11013353.

14. Arai T, Esaki Y, Inoshita N, Sawabe M, Kasahara I, Kuroiwa K, et al. Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients. Gastric cancer. 2004; 7:154–159. PMID: 15449203.

15. Kaibara N, Maeta M, Ikeguchi M. Patients with multiple primary gastric cancers tend to develop second primaries in organs other than the stomach. Surg Today. 1993; 23:186–188. PMID: 8467167.

16. Yokozaki H, Semba S, Fujimoto JY, Tahara E. Microsatellite instabilities in gastric cancer patients with multiple primary cancers. Int J Oncol. 1999; 14:151–155. PMID: 9863022.

17. Miyoshi E, Haruma K, Hiyama T, Tanaka S, Yshihara M, Shimamoto F, et al. Microsatellite instability is a genetic marker for the development of multiple gastric cancers. Int J Cancer. 2001; 95:350–353. PMID: 11668515.