Clin Mol Hepatol.
2015 Dec;21(4):319-325. 10.3350/cmh.2015.21.4.319.
Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase
- Affiliations
-
- 1Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA. yasuko.iwakiri@yale.edu
- KMID: 2359812
- DOI: http://doi.org/10.3350/cmh.2015.21.4.319
Abstract
- The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.
MeSH Terms
-
Endothelial Cells/metabolism
Hepatic Stellate Cells/metabolism
Humans
Kupffer Cells/metabolism
Liver Cirrhosis/metabolism/*pathology
Nitric Oxide/*metabolism
Nitric Oxide Synthase Type II/antagonists & inhibitors/genetics/*metabolism
Polymorphism, Single Nucleotide
RNA, Untranslated/metabolism
RNA, Untranslated
Nitric Oxide
Nitric Oxide Synthase Type II
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Involvement of Fibronectin in the Migration of Macrophage and Expression of Nitric Oxide Synthase in the BCG induced Inflammatory Sites in Rat Bladder
- Role of nitric oxide and distribution of nitric oxide synthase in the gustatory system
- The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention
- Expression of Constitutive Nitric Oxide Synthase by Gastrointestinal Epithelial Cells
- Nitric oxide production and inducible nitric oxide synthase expression induced by Porphyromonas gingivalis lipopolysaccharide
