J Cancer Prev.  2016 Mar;21(1):1-12. 10.15430/JCP.2016.21.1.1.

The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention

• Vahora H
• Khan MA
• Alalami U
• Hussain A

• KMID: 2161517
• DOI: http://doi.org/10.15430/JCP.2016.21.1.1

Abstract

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in this regard still remains unanswered. This review summarizes the recent information on NO and its role in carcinogenesis and tumor progression, as well as dietary chemopreventive agents which have NO-modulating properties with safe cytotoxic profile. Understanding the molecular mechanisms and cross-talk modulating NO effect by these chemopreventive agents can allow us to develop better therapeutic strategies for cancer treatment.

Keyword

Chemoprevention; Nitric oxide; Inducible nitric oxide synthase; Endothelial nitric oxide synthase; Neoplasms

MeSH Terms

Carcinogenesis
Chemoprevention*
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Nitric Oxide*
Nitric Oxide
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III