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Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase

Iwakiri Y

The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could...
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Pathophysiology of Portal Hypertension, What's New?

Kim MY, Baik SK

Portal hypertension (PHT) is associated with changes in the intrahepatic, systemic and portosystemic collateral circulations. Alteration in vasoreactivity (vasodilation and vasoconstriction) plays a central role in the pathogenesis of PHT...
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Negative-pressure wound therapy induces endothelial progenitor cell mobilization in diabetic patients with foot infection or skin defects

Seo SG, Yeo JH, Kim JH, Kim JB, Cho TJ, Lee DY

  • KMID: 2154281
  • Exp Mol Med.
  • 2013 Nov;45(11):e62.
Non healing chronic wounds are difficult to treat in patients with diabetes and can result in severe medical problems for these patients and for society. Negative-pressure wound therapy (NPWT) has...
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Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques

Lee SJ, Paeng JC

Atherosclerosis is an inflammatory disease as well as a lipid disorder. Atherosclerotic plaque formed in vessel walls may cause ischemia, and the rupture of vulnerable plaque may result in fatal...
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Effects of the knockdown of hypoxia inducible factor-1alpha expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines

Choi SH, Shin HW, Park JY, Yoo JY, Kim DY, Ro WS, Yun CO, Han KH

BACKGROUND/AIMS: Hypoxia-inducible factor-1alpha (HIF-1alpha) is a central transcriptional factor involved in the cellular responses related to various aspects of cancer biology, including proliferation, survival, and angiogenesis, and the metabolism of...
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Hemodynamic alterations in cirrhosis and portal hypertension

Kim MY, Baik SK, Lee SS

Portal hypertension (PHT) is associated with hemodynamic changes in intrahepatic, systemic, and portosystemic collateral circulation. Increased intrahepatic resistance and hyperdynamic circulatory alterations with expansion of collateral circulation play a central...
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Interferon-Stimulated Genes Response in Endothelial Cells Following Hantaan Virus Infection

Kim IW, Hwang JY, Kim SK, Kim JK, Park HS

The regulation mechanism of interferon (IFN) and IFN-stimulated genes is a very complex procedure and is dependent on cell types and virus species. We observed molecular changes related to anti-viral...
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A novel way of therapeutic angiogenesis using an adeno-associated virus-mediated angiogenin gene transfer

Cho YH, Park H, Cho ES, Kim WJ, Kang BS, Park BY, Kim YJ, Lee YI, Chang SI, Park K

  • KMID: 1047093
  • Exp Mol Med.
  • 2007 Jun;39(3):412-418.
To develop a novel therapeutic angiogenesis for the treatment of cardiovascular diseases, angiogenin (ANG1) was examined as a potential therapeutic gene. An adeno-associated virus (AAV)-mediated gene delivery system was used...
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