Nucl Med Mol Imaging.  2016 Sep;50(3):258-260. 10.1007/s13139-016-0394-0.

Brain ¹⁸F-FDG, ¹⁸F-Florbetaben PET/CT, ¹²³I-FP-CIT SPECT and Cardiac ¹²³I-MIBG Imaging for Diagnosis of a "Cerebral Type" of Lewy Body Disease

• Van Der Gucht A
• Cleret de Langavant L
• Bélissant O
• Rabu C
• Cottereau
• Evangelista E
• Chalaye J
• Bonnot-Lours S
• Fènelon G
• Itti E

• KMID: 2351651
• DOI: http://doi.org/10.1007/s13139-016-0394-0

Abstract

A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. ¹â¸F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but ¹²³I-FP-CIT SPECT was normal and cardiac ¹²³I-MIBG imaging showed no signs of sympathetic denervation. Alzheimer's disease was excluded by a normal ¹â¸F-florbetaben PET/CT. This report suggests a rare case of α-synucleinopathy without brainstem involvement, referred to as "cerebral type" of Lewy body disease.

Keyword

Brain imaging; ¹⁸F-FDG; ¹⁸F-florbetaben; ¹²³I-FP-CIT; Lewy body disease; (MeSH terms); MIBG

MeSH Terms

3-Iodobenzylguanidine
Aged
Alzheimer Disease
Brain Stem
Brain*
Depression
Diagnosis*
Hallucinations
Humans
Lewy Bodies*
Lewy Body Disease*
Neuroimaging
Occipital Lobe
Parkinsonian Disorders
Positron-Emission Tomography and Computed Tomography*
Sympathectomy
Tomography, Emission-Computed, Single-Photon*
3-Iodobenzylguanidine