J Korean Neuropsychiatr Assoc.  2001 Nov;40(6):1223-1230.

Polymorphism of CYP2D6*10B of Patients with Schizophrenia in Korean Population

• Kim CE
• Roh HK
• Moon HW
• Koh JK
• Park CS

Abstract

OBJECTIVES
This study was done to compare the proportion of the CYP2D6*10 allele between previously reported data of normal Korean subjects and schizophrenic patients. And we investigated the relationship between the CYP2D6*10 allele and the clinical variables such as age of onset, duration of illness and psychopathology.
METHODS
Total 82 DSM-IV Korean schizophrenic patients in monotherapy with risperidone participated in this study. The CYP2D6*10 allele which contains C188T mutation in exon 1 was identified by allele specific PCR amplification. We investigated the clinical variables such as age of onset and duration of illness through chart review. The baseline psychopathology with brief psychiatric rating scale (BPRS) before blood collection were done in clinically stable patients.
RESULTS
Seventeen (20.7%) out of 82 patients were homozygous for CYP2D6*1, 22 (26.8%) for *10, while the remaining 43 patients (52.4%) were heterozygous for these alleles. These distributions were very similar with previously reported data of Korean normal subjects. There was no significant relationship between the CYP2D6*10 allele and the clinical variables such as age of onset, duration of illness and psychopathology.
CONCLUSION
In Korean schizophrenic patients, there was no significant difference in CYP2D6*10 allele compared to normal Korean subjects.

Keyword

Schizophrenia; CYP2D6; Polymorphism; PCR

MeSH Terms

Age of Onset
Alleles
Brief Psychiatric Rating Scale
Cytochrome P-450 CYP2D6
Diagnostic and Statistical Manual of Mental Disorders
Exons
Humans
Polymerase Chain Reaction
Psychopathology
Risperidone
Schizophrenia*
Cytochrome P-450 CYP2D6
Risperidone