- Selection of an Antidepressant Based on the Genotypes of Cytochrome P450 Enzymes Genes in a Patient with Major Depressive Disorder
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Ryu S, Lee SY, Kim JW, Hong KS
- KMID: 2286815
- Korean J Psychopharmacol.
- 2005 Jul;16(4):324-328.
We present a case of 34-year-old female patient with major depressive disorder who had decreased metabolic activity of CYP2D6. Low dosage regimen of mirtazapine & paroxetine led to unexpectedly severe... -
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- Antipsychotics Induced Etrapyramidal Symptoms in Schizophrenics in Relation to Cytochrome P450 2D6 Genotype
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Lee MS, Nam JW
- KMID: 2334618
- J Korean Soc Biol Psychiatry.
- 1999 Nov;6(2):189-192.
The genetically determined CYP2D6 activity may be considered to be associated with antipsychotic induced extrapyramidal side effects with inter-individual variation. Genetic polymorphism of CYP2D6 was determined by polymerase chain reaction(PCR)... -
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- A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity
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Song M, Do H, Kwon OK, Yang EJ, Bae JS, Jeong TC, Song KS, Lee S
- KMID: 2170656
- Biomol Ther.
- 2014 Mar;22(2):155-160.
Thelephoric acid is an antioxidant produced by the hydrolysis of polyozellin, which is isolated from Polyozellus multiplex. In the present study, the inhibitory effects of polyozellin and thelephoric acid on... -
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- Prolonged Drug-Drug Interaction between Terbinafine and Perphenazine
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Park YM
- KMID: 2316237
- Psychiatry Investig.
- 2012 Dec;9(4):422-424.
I report here an elderly woman receiving perphenazine together with terbinafine. After 1 week of terbinafine treatment she experienced extrapyramidal symptoms and, in particular, akathisia. Her symptoms did not disappear... -
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- PCR and RFLP-based CYP2D6(B) and CYP2D6(T) Genotyping for Korean Lung Cancer Cases and Controls
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Chun JH, Lee CH, Urm SH, Son BC, Park JH, Jung KO, Sohn CH, Yoon HK, Son CH, Kim HI, Kim JS
- KMID: 2282910
- Korean J Prev Med.
- 1998 Mar;31(1):1-14.
The genetically determined CYP2D6 activity is considered to be associated with cancer susceptibility with inter-individual variation. Genetic polymorphism of CYP2D6(B) and CYP2D6(T) was determined by the two polymerase chain reaction(PCR)... -
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- A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
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Lee SY, Ki CS, Hong KS, Kim JW
- KMID: 1733521
- J Korean Med Sci.
- 2004 Oct;19(5):750-752.
- doi: 10.3346/jkms.2004.19.5.750
We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT... -
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- No Association of CYP2D6*4 and CYP2D6*10 Polymorphisms with Tardive Dyskinesia in Korean Schizophrenics
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Woo SI, Kang DW, Seo HG, Kim BJ, Lee IS, Jeong GH, Park SY, Jung CY, Lee HC, Jeong KC, Sohn JW
- KMID: 1899247
- J Korean Soc Biol Psychiatry.
- 2000 Nov;7(2):140-146.
P450 CYP2D6 enzyme(debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association... -
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- CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression
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Han KM, Chang HS, Choi IK, Ham BJ, Lee MS
- KMID: 2316302
- Psychiatry Investig.
- 2013 Sep;10(3):286-293.
OBJECTIVE: Cytochrome P450 (CYP) enzymatic activity, which is influenced by CYP genetic polymorphism, is known to affect the inter-individual variation in the efficacy and tolerability of antidepressants in major depressive... -
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- Correlation between Genetic Polymorphism of CYP2D6 and CYP1A1 and Susceptibility of Renal Cell Carcinoma in Korean
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Park KW, Jung SI, Jung GW, Kwon HY, Jeong JS, Chun JH, Yoon JH
- KMID: 2007098
- J Korean Cancer Assoc.
- 2000 Aug;32(4):801-809.
PURPOSE: Many of the enzymes handling environmental factors are polymorphic and may confer variable susceptibility to renal cell carcinoma (RCC). Among those, the author studied genetic polymorphisms of CYP2D6 (B... -
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- Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans
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Lim YJ, Cha EY, Jung HE, Ghim JL, Lee SJ, Kim EY, Shin JG
- KMID: 2050939
- Transl Clin Pharmacol.
- 2014 Dec;22(2):70-77.
- doi: 10.12793/tcp.2014.22.2.70
The Vietnamese-Koreans, especially offspring between a Vietnamese mother and a Korean father constituted the highest proportion (64.2%) of total Kosian population according to a census in 2014. To evaluate genetic... -
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- Relationship of Polymorphism of Cytochrome P-450 2D6 and Clinical Outcomes of Paroxetine in Korean Depressive Disorders Patients
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Oh KS, Lee MS
- KMID: 2037078
- Korean J Psychopharmacol.
- 2000 Sep;11(3):262-269.
OBJECTIVE: The polymorphism of cytochrome P-450 2D6 (CYP2D6) is responsible for the metabolism of psychotrophics including antidepressants such as paroxetine. In order to maximize the clinical effects and minimize the... -
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- Genetic Polymorphism of CYP2D6 and Clomiphene Concentrations in Infertile Patients with Ovulatory Dysfunction Treated with Clomiphene Citrate
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Ji M, Kim KR, Lee W, Choe W, Chun S, Min WK
- KMID: 2360058
- J Korean Med Sci.
- 2016 Feb;31(2):310-314.
- doi: 10.3346/jkms.2016.31.2.310
CYP2D6 is primarily responsible for the metabolism of clomiphene citrate (CC). The purpose of the present study was to investigate the relationship between CYP2D6 genotypes, concentrations of CC and its... -
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- Drug Interactions between Cardiovascular Agents and Psychotropic Drugs
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Park JE, Jung KH
- KMID: 1445924
- Korean J Psychosom Med.
- 2011 Dec;19(2):57-65.
There are numerous drug interactions related to many psychotropic and cardiovascular medications. Firstly, the principles in predicting drug interactions are discussed. Cytochrome P (CYP) 450 plays a significant role in... -
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- CYP2D6 and NAT2 Polymorphism in HBV Associated in Hepatocellular Carcinoma Patients in Korea
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Shin DI, Lee KG, Lee KS, Cho YH
- KMID: 1940657
- J Korean Surg Soc.
- 2002 Feb;62(2):150-156.
PURPOSE: CYP2D6 and N-acetyltransferase (NAT2) are polymorphic enzymes which are expressed in the hepatocyte in a genotype-determined manner. They are known to be involved in the inactivation and activation of... -
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- Polymorphism of CYP2D6*10B of Patients with Schizophrenia in Korean Population
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Kim CE, Roh HK, Moon HW, Koh JK, Park CS
- KMID: 2340630
- J Korean Neuropsychiatr Assoc.
- 2001 Nov;40(6):1223-1230.
OBJECTIVES: This study was done to compare the proportion of the CYP2D6*10 allele between previously reported data of normal Korean subjects and schizophrenic patients. And we investigated the relationship between... -
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- Prediction and visualization of CYP2D6 genotype-based phenotype using clustering algorithms
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Kim EY, Shin SG, Shin JG
- KMID: 2390935
- Transl Clin Pharmacol.
- 2017 Sep;25(3):147-152.
- doi: 10.12793/tcp.2017.25.3.147
This study focused on the role of cytochrome P450 2D6 (CYP2D6) genotypes to predict phenotypes in the metabolism of dextromethorphan. CYP2D6 genotypes and metabolic ratios (MRs) of dextromethorphan were determined... -
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- pharmacogenomics and Schizophrenia
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Lee KY, Chung IW
- KMID: 2202801
- J Korean Soc Biol Psychiatry.
- 2001 Nov;8(2):208-219.
The pharmacotherapy of schizophrenia exhibit wide inter-individual variabilities in clinical efficacy and adverse effects. Recently. human genetic diversity has been known as one of the essential factors to the variation... -
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- Pharmacogenetics and Depression: A Critical Perspective
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Corponi F, Fabbri C, Serretti A
- KMID: 2459684
- Psychiatry Investig.
- 2019 Sep;16(9):645-653.
- doi: 10.30773/pi.2019.06.16
Depression leads the higher personal and socio-economical burden within psychiatric disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal response still poses a major challenge and is... -
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- Use of Antidepressants in Patients with Breast Cancer Taking Tamoxifen
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Kim SH, Lee MR, Lee KC, Lee JH, Kwon HC, Kim DC, Lee KW, Cho SH
- KMID: 2286520
- J Breast Cancer.
- 2010 Dec;13(4):325-336.
- doi: 10.4048/jbc.2010.13.4.325
Tamoxifen, a selective estrogen modulator has been used for more than three decades to treat all stages of estrogen receptor (ER)-positive breast cancer and to prevent the disease. Tamoxifen is... -
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- Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer
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Lee HC, Yoon YB, Kim CY
- KMID: 1051581
- Korean J Intern Med.
- 1997 Jun;12(2):128-136.
OBJECTIVES: Metabolic activation is a prerequisite for the carcinogenic effect of many carcinogens, and considerable interindividual variation exists in the metabolic capacity to activate the carcinogens. The cytochromes P-450 (CYPs)... -
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