J Korean Neuropsychiatr Assoc.  1999 Jan;38(1):147-155.

No Association between 102T/C and 452His/Tyr Polymorphisms of 5-HT2A Receptor Gene and Schizophrenia in Korean Population

• Lee SK
• Wang SK
• Chee IS
• Lee YH
• Shin SC

Abstract

OBJECTIVES: This study was designed to investigate the association between the silent mutation, 102T/C and the substitution of histidine by tyrosine at position 452, 452His/Tyr polymorphism of the 5HT2A receptor gene and schizophrenia in korean population. METHOD: 102T/C and 452His/Tyr polymorphism of the 5-HT2A receptor gene was typed with PCR in 93 patients with schizophrenia and 93 healthy controls.
RESULTS
1) Genotype of 102T/T, 102T/C, 102C/C were 37(40%), 34(36%), and 22(24%), res-pectively in the patients with schizophrenia. Genotype of 102T/T, 102T/C, 102C/C were 31(33%), 41(44%), and 21(23%), respectively in the controls, Allele frequencies of 102T in the patients with schizophrena was 0.58 and that in the controls was 0.55. Allele frequencies of 102C in the patients with schizophrena was 0.42 and that in controls was 0.45. There were no differencies in genotype and allele frequency of 102T/C between the patients with schizophrenia and the controls. 2) 452His/Tyr polymorphism of the 5-HT2A receptor gene was not founeded in the patients with schizophrenia and in the controls.
CONCLUSION
These results suggest 102T/C and 452His/Tyr polymorphisms of the 5-HT2A receptor gene are not causally related to the development of schizophrenia in Korean population.

Keyword

Schizophrenia; 5-HT2A receptor gene; 102T/C polymorphism; 452His/Tyr polymorphism; Association study

MeSH Terms

Gene Frequency
Genotype
Histidine
Humans
Polymerase Chain Reaction
Receptor, Serotonin, 5-HT2A*
Schizophrenia*
Tyrosine
Histidine
Receptor, Serotonin, 5-HT2A
Tyrosine