J Korean Neuropsychiatr Assoc.  2005 Jan;44(1):25-31.

-1438A/G Polymorphism of the 5-HT2A Receptor Gene in Korean and Han Chinese Patients with Schizophrenia

• Yi JH
• Li GZ
• Li SF
• Wu LR
• Chui YG
• Cho AR
• Chung JH
• Chang HI

Abstract

OBJECTIVES
The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population.
METHODS
A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Restriction Fragment Length Polymorphism (RFLP).
RESULTS
There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G polymorphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics.
CONCLUSION
These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.

Keyword

Schizophrenia; 5-HT2A receptor gene; -1438A/G polymorphism

MeSH Terms

Asian Continental Ancestry Group*
Genotype
Humans
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Receptor, Serotonin, 5-HT2A*
Schizophrenia*
Receptor, Serotonin, 5-HT2A