J Neurogastroenterol Motil.  2012 Apr;18(2):205-210.

G-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome

• Kim HG
• Lee KJ
• Lim SG
• Jung JY
• Cho SW

Abstract

BACKGROUND/AIMS
Guanine nucleotide binding protein (G-protein) beta polypeptide 3 (GNB3) C825T polymorphism alters intracellular signal transduction, which may lead to motor or sensory abnormalities of the gastrointestinal tract. The aim of the present study was to evaluate the association of the GNB3 C825T polymorphism with susceptibility to overlap syndrome of functional dyspepsia (FD) and irritable bowel syndrome (IBS) in a Korean population.
METHODS
One hundred sixty-seven patients with FD alone, 60 patients with IBS alone, 85 patients with the overlap of FD and IBS, and 434 asymptomatic healthy subjects participated in the study. Genotyping for GNB3 C825T polymorphism was performed using their blood samples.
RESULTS
No association of GNB3 genotypes in patients with FD alone, IBS alone or overlap phenotype, when compared to genotypes in controls, was detected. The frequency of CT and TT genotypes relative to the CC genotype for the phenotypes of FD alone, IBS alone and the coexistence of FD and IBS did not significantly differ. Comparison of the TT genotype with the CC/CT genotype showed no significant association for each phenotype group.
CONCLUSIONS
There is no apparent association of the GNB3 C825T polymorphism with the susceptibility to FD, IBS or the overlap of FD and IBS. Larger-scale studies and further investigation on other candidate genes are required.

Keyword

Functional dyspepsia; G-protein beta3 subunit; Irritable bowel syndrome; Syndrome

MeSH Terms

Carrier Proteins
Dyspepsia
Gastrointestinal Tract
Genotype
GTP-Binding Proteins
Guanine
Heterotrimeric GTP-Binding Proteins
Humans
Irritable Bowel Syndrome
Phenotype
Signal Transduction
Carrier Proteins
GTP-Binding Proteins
Guanine
Heterotrimeric GTP-Binding Proteins