J Korean Acad Prosthodont.  2011 Jul;49(3):254-262.

Review of the developmental trend of implant surface modification using organic biomaterials

• Hwang ST
• Han IH
• Huh JB
• Kang JK
• Ryu JJ

Abstract

PURPOSE
This study aims to evaluate and prospect for current research trend and developmental perspectives via analyzing recent biomaterial coated-implants study.
MATERIALS AND METHODS
To investigate each subject respectively, several biomaterials that are using for implant surface coating were set as 'keywords'. By these keywords, major research groups in each subject were chosen, and research trend of them was analyzed. Trend of In vivo studies that examined selected biomaterials were analyzed to evaluate commercial potential.
RESULTS
The collagen research accounted for 40% of total implant study, which was the highest, and fibronectin, BMPs (bone morphogenetic proteins) and RGD (Arg-Gly-Asp) peptides followed, which were ranked in descending order. Furthermore, figures of all four research subjects were also increased with time, especially a sharp increase in RGD research. According to the results of major research group, collagen that was combined with other organic and inorganic biomaterials was mostly examined, rather than using collagen only. Major research groups investigating BMPs mostly focused on rhBMP-2. In animal studies, collagen was used as resorbable membrane in guided bone regeneration (GBR) or drug carrier, while BMPs were used with bone graft materials or coating material for titanium implant surface.
CONCLUSION
There is not consistency of results even in identical subjects research field. Many studies are ongoing to optimize combination between mechanical surface treatment and biomaterials such as extracellular matrix component and growth factors.

Keyword

Dental implant; Surface modification; Biomolecule; Extracellular matrix; Growth factor

MeSH Terms

Animals
Biocompatible Materials
Bone Regeneration
Collagen
Dental Implants
Drug Carriers
Extracellular Matrix
Fibronectins
Humans
Intercellular Signaling Peptides and Proteins
Membranes
Peptides
Research Subjects
Titanium
Transplants
Biocompatible Materials
Collagen
Dental Implants
Drug Carriers
Fibronectins
Intercellular Signaling Peptides and Proteins
Peptides
Titanium

Figure

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  Fig. 1. Relative % ratio of search words related with bioactive organic materials in all years.

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  Fig. 2. Relative % ratio of search words related with bioactive organic materials in recent 5 years.

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  Fig. 3. Relative % ratio of search words related with bioactive organic materials in recent 3 years.

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  Fig. 4. Comparison of the number of articles in search words related with bioactive organic materials in 5-year unit period.

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  Fig. 5. Comparison of the number of articles in search words related with bioactive organic materials in recent 5 years.

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  Fig. 6. Comparison of accumulative frequency of subject studied with collagen by Scharnweber et al.

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  Fig. 7. Changes of frequency of subject studied with collagen according to published year by Scharnweber et al.

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  Fig. 8. Comparison of accumulative frequency of subject according to use of collagen: 24 dog model studies.

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  Fig. 9. Comparison of frequency of subject according to published year: 24 dog model studies.

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