Tuberc Respir Dis.  2009 Feb;66(2):122-126.

A Case of Nonclassifiable Interstitial Pneumonia after Allogeneic Hematopoietic Stem Cell Transplantation

• Jung KH
• Sung HJ
• Lee JH
• Han J
• Shin C
• Park HJ
• Kim JH

Abstract

Despite the improvements in supportive care, early and late hematopoietic stem cell transplantation-related complications still remain a significant cause of morbidity and mortality. Pulmonary complications occur in 40~60% of patients who undergo allogeneic hematopoietic stem cell transplantation. Late-onset noninfectious pulmonary complications can occur months and even years after transplantation. Interstital lung disease has also been reported to be a late post-transplant complication. Exposure to cytotoxic drugs and/or irradiation has been implicated as a cause of pulmonary toxicity including pulmonary fibrosis. We report a case of an 18-year-old female with non-classifiable interstitial pneumonia that manifested eight and a half years after allogeneic hematopoietic stem cell transplantation. The condition worsened rapidly and the patient eventually died.

Keyword

Hematopoietic stem cell transplantation; Interstitial lung disease; Pneumothorax

MeSH Terms

Adolescent
Female
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Humans
Lung Diseases
Lung Diseases, Interstitial
Pneumothorax
Pulmonary Fibrosis
Transplants