Tuberc Respir Dis.  2006 Oct;61(4):330-338.

Relationship between Systemic Inflammatory Marker, Oxidative Stress and Body Mass Index in Stable COPD Patient

• Ham HS
• Lee HY
• Lee SJ
• Cho YJ
• Jung YY
• Kim HC
• Hahm JR
• Park CH
• Lee JD
• Sohn HJ
• Youn HS
• Hwang YS

Abstract

BACKGROUND: The main factors associated with weight loss in patients with COPD are not well known. Since chronic inflammation and oxidative stress play a major pathogenic role in COPD, these factors may be responsible for the patients' weight loss. Therefore, this study measured the body mass index (BMI) in COPD patients and evaluated the variables, such as systemic inflammatory marker, oxidative stress and lung function, that correlate with the BMI. METHOD: The stable COPD patients (M:F=49:4, mean age=68.25+/-6.32) were divided into the lower (<18.5), normal (18.5-25) and higher (>25) BMI group. The severity of the airway obstruction was evaluated by measuring the FEV1. The serum IL-6 and TNF-alpha levels were measured to determine the degree of systemic inflammation, and the carbonyl protein and 8-iso-prostaglandin F2alpha level was measured to determine the level of oxidative stress. Each value in the COPD patients and normal control was compared with the BMI.
RESULTS
1) Serum 8-iso-prostaglandin F2alpha in COPD patients was significantly higher (456.08+/-574.12 pg/ml) than that in normal control (264.74+/-143.15 pg/ml) (p<0.05). However, there were no significant differences in the serum IL-6, TNF-alpha, carbonyl protein between the COPD patients and normal controls. 2). In the COPD patients, the FEV1 of the lower BMI group was significantly lower (0.93+/-0.25L) than that of the normal BMI (1.34+/-0.52L) and higher BMI groups (1.72+/-0.41L) (p<0.05). The lower FEV1 was significantly associated with a lower BMI in COPD patients (p=0.002, r=0.42). The BMI of very severe COPD patients was significantly lower (19.8+/-2.57) than that of the patients with moderate COPD (22.6+/-3.14) (p<0.05). 3). There were no significant differences in the serum IL-6, TNF-alpha, carbonyl protein and 8-iso-prostaglandin F2alpha according to the BMI in the COPD patients.
CONCLUSION
The severity of the airway obstruction, not the systemic inflammatory markers and oxidative stress, might be associated with the BMI in stable COPD patients. Further study will be needed to determine the factors associated with the decrease in the BMI of COPD patients.

Keyword

COPD; Oxidative stress; Systemic inflammatory marker; BMI

MeSH Terms

Airway Obstruction
Body Mass Index*
Humans
Inflammation
Interleukin-6
Lung
Oxidative Stress*
Pulmonary Disease, Chronic Obstructive*
Tumor Necrosis Factor-alpha
Weight Loss
Interleukin-6
Tumor Necrosis Factor-alpha

Figure

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  Figure 1 Serum IL-6 and TNF-α in normal control and COPD patients. *p value>0.05 compared with normal control.

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  Figure 2 Serum 8-iso-prostaglandin F2α and carbonyl protein in normal control and COPD patients. *p value<0.05 compared with normal control.

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  Figure 3 FEV1(L) value according to BMI and its relation with BMI in COPD patients. There was significant correlation between FEV1 and BMI (p<0.05, r=0.42). *p value<0.05 compared with normal and higher BMI.

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  Figure 4 Difference of BMI according to severity of COPD. *P value<0.05 compared with moderate COPD.

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  Figure 5 Serum IL-6 and TNF-α according to BMI in COPD patients. *p value>0.05 compared with lower and higher BMI.

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  Figure 6 Serum 8-iso-prostaglandin F2α and carbonyl protein according to BMI in stable COPD patients. *p value>0.05 compared with normal and higher BMI.

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