Soonchunhyang Med Sci.
2012 Dec;18(2):95-101.
An Immunohistochemical Study on the Expression of SUMO-2/3 in the Colorectal Carcinoma
- Affiliations
-
- 1Department of Health Management, Hanseo University, Seosan, Korea.
- 2Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea. juny1024@sch.ac.kr
- 3Department of Preventive Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
Abstract
OBJECTIVE
The incidence of colorectal carcinomas continues to rise in Korea due to the westernized life style. However, the precise colorectal carcinogenic mechanisms remain to be elucidated. The protein products of oncogenes and cancer suppressor genes play important roles in the carcinogenesis. The effects of the proteins are influenced by post-translational modifications as phosphorylation, acetylation, methylation, and ubiquitination. The aberrant sumoylation plays some roles in carcinogenesis. However, the expression pattern of small ubiquitin-related modifier (SUMO)-2/3 in the colorectal cancer has not been reported. We assessed the expression of SUMO-2/3 and evaluated the expression pattern in colorectal cancer.
METHODS
The SUMO-2/3 expression was tested in one normal colon mucosal cell line and 5 colorectal cancer cell lines by Western blot. We collected 322 cases of colorectal cancer operated from January 2000 to December 2010 at Soonchunhyang University Cheonan Hospital. We fabricated the tissue microarray and the expression of SUMO-2/3 was evaluated by immunohistochemistry. The results were analyzed with clinicopathologic parameters.
RESULTS
The SUMO-2/3 was not expressed in the normal colon mucosal cell line. However, it was expressed highly in all the 5 colorectal cancer cell lines as the beta-actin. The SUMO-2/3 was expressed in 68.3% of the colorectal cancers and its expression was correlated with the pathological tumor stage stage (odds ratio, 2.89; 95% confidence interval, 1.10 to 7.55; P=0.031).
CONCLUSION
The SUMO-2/3 plays some roles in carcinogenesis and progression of the colorectal cancer.
Keyword
MeSH Terms
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- nm23 Protein Immunohistochemical Expression in Colorectal Carcinoma and its Relationship with Other Prognostic Factors
- A Study on the Expression of p53 and nm23 Protein in the Colorectal Adenoma and Carcinoma
- Reduced E-Cadherin Expression as a Cause of Distinctive Signet-Ring Cell Variant in Colorectal Carcinoma
- Clinical Significance of PCNA and nm23 Expression in Invasive Colorectal Carcinoma
- Immunohistochemical Study of p53 Protein Expression in Colorectal Tumors
