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Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells

Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS

PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. Peroxiredoxin-6, an important intracellular anti-oxidant...
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Positioning Metabolism as a Central Player in the Diabetic Heart

Mereweather LJ, Montes Aparicio CN, Heather LC

In type 2 diabetes (T2D), the leading cause of death is cardiovascular complications. One mechanism contributing to cardiac pathogenesis is alterations in metabolism, with the diabetic heart exhibiting increased fatty...
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Analysis of the transcripts encoding for antigenic proteins of bovine gammaherpesvirus 4

Romeo F, Spetter MJ, Moran P, Pereyra S, Odeon A, Perez SE, Verna AE

The major glycoproteins of bovine gammaherpesvirus 4 (BoHV-4) are gB, gH, gM, gL, and gp180 with gB, gH, and gp180 being the most glycosylated. These glycoproteins participate in cell binding...
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Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review

Kim H, Kang JS, Jeong HJ

Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated...
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Plant factory: new resource for the productivity and diversity of human and veterinary vaccines

Shim BS, Hong KJ, Maharjan P, Choe S

Vaccination is one of the most successful strategies to prevent diseases caused by pathogens. Although various expression systems including Escherichia coli, yeast, insect, and mammalian cells are currently used for...
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The Nedd8-activating enzyme inhibitor MLN4924 suppresses colon cancer cell growth via triggering autophagy

Lv Y, Li B, Han K, Xiao Y, Yu X, Ma Y, Jiao Z, Gao J

Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the...
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Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism

Park S, Jeon JH, Min BK, Ha CM, Thoudam T, Park BY, Lee IK

Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial...
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Glycolysis and the Hexosamine Biosynthetic Pathway as Novel Targets for Upper and Lower Airway Inflammation

Kim YH, Nakayama T, Nayak J

Glycolysis is a process that rapidly converts glucose to lactate to produce adenosine triphosphate (ATP) under anaerobic conditions and occurs in all eukaryotic and prokaryotic cells. On the other hand,...
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Analysis of structure-function relationship in porcine rotavirus A enterotoxin gene

Saurabh S, Sircar S, Kattoor JJ, Ghosh S, Kobayashi , Banyai K, VinodhKumar OR, De UK, Sahoo NR, Dhama K, Malik YS

Rotavirus (RV)-infected piglets are presumed to be latent sources of heterologous RV infection in humans and other animals. In RVs, non-structural protein 4 (NSP4) is the major virulence factor with...
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RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment

Hong S

After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA...
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Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs

Nikolaou G, Zibis AH, Fyllos AH, Katsioulis A, Sotiriou S, Kotrotsios A, Sgantzos M, Vassiou A, Arvanitis

STUDY DESIGN: Human herniated discs were obtained from discectomy specimens for the immunohistochemical detection of O-GlcNAc and O-GlcNAcase (OGA)/O-GlcNAc transferase (OGT). PURPOSE: This study aimed to quantify the extent of O-GlcNAcylation...
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New Aspects of Vascular Calcification: Histone Deacetylases and Beyond

Kwon DH, Kim YK, Kook H

Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases,...
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Survive or thrive: tradeoff strategy for cellular senescence

Park SC

Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in...
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Gut Microbiome, a Potent Modulator of Epigenetics in Human Diseases

Kim JA

Human physiology and pathology can be affected by different nutritional conditions. At cellular level, the availability of a nutritional component not only mediates metabolic reactions but also transmits signals for...
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Histone lysine demethylases in mammalian embryonic development

Shen H, Xu W, Lan F

Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas...
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My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy

Brahma MK, Pepin ME, Wende AR

Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level...
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Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis

Zhang X, Kim KM

Endocytosis is a process by which cells absorb extracellular materials via the inward budding of vesicles formed from the plasma membrane. Receptor-mediated endocytosis is a highly selective process where receptors...
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Epigenetic regulation and chromatin remodeling in learning and memory

Kim S, Kaang BK

Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the...
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Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells

Choi BH, Lee DH, Kim J, Kang JH, Park CS

Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5'-AMP-activated protein kinase (AMPK) activators such...
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F-box only protein 9 is an E3 ubiquitin ligase of PPARγ

Lee KW, Kwak SH, Koo YD, Cho YK, Lee HM, Jung HS, Cho YM, Park YJ, Chung SS, Park KS

Peroxisome proliferator-activated receptor gamma (PPARγ) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Post-translational modification of PPARγ and its degradation involve several pathways, including...
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