Int Neurourol J.  2016 Mar;20(1):5-12. 10.5213/inj.1632570.285.

Rescue of Heart Failure by Mitochondrial Recovery

• Marquez J
• Lee SR
• Kim N
• Han J

• KMID: 2173121
• DOI: http://doi.org/10.5213/inj.1632570.285

Abstract

Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further progression of HF. Mitochondria undoubtedly play an important role in the progression of HF, and numerous studies have highlighted mitochondrial components that contribute to HF. This review presents an overview of the role of mitochondrial biogenesis, mitochondrial oxidative stress, and mitochondrial permeability transition pore in HF, discusses ongoing studies that attempt to address the disease through mitochondrial targeting, and provides an insight on how these studies can affect future research on HF treatment.

Keyword

Mitochondria; Heart Failure; Oxidative Stress; Protein Processing, Post-Translational; Mitochondrial Permeability Transition Pore

MeSH Terms

Heart Failure*
Heart*
Mitochondria
Organelle Biogenesis
Oxidative Stress
Permeability
Protein Processing, Post-Translational