Pediatr Allergy Respir Dis.  2006 Jun;16(2):171-176.

A Case of Toxic Epidermal Necrolysis Treated with High Dose Intravenous Immunoglobulin in a 2 Years Old Boy

• Jeon SY
• Nam JH
• Han SM
• Rhue KH
• Lee SY
• Park JS

Abstract

Toxic epidermal necrolysis(TEN) is a severe drug induced life-threatening disease and an acute illness. This disease is characterized by rapid onset of widespread necrosis resulting in sloughing of epidermis. The incidence of TEN is very rare, with approximately 0.5 to 1.4 cases per million per year. but TEN has a high mortality rate of 25-40 percent. Therapy for TEN is primarily aimed at supportive care. Treatment with systemic corticosteroid, immunosuppresive agent such as cyclosporine, cyclophosphamide, pentoxifyllin or plasmapheresis have not been shown to improve outcome. Recently, administration of high dose intravenous immunoglobulin(IVIG) has been shown to result in rapid improvement in patients with TEN. There have been several reports of the benefit of IVIG in adult patients with TEN. However we could not find using IVIG in pediatric patient with TEN in Korea. We have experienced improvement in a 2 years old boy with TEN after using high dose IVIG.

Keyword

Toxic epidermal necrolysis; Intravenous immunoglobuline; Children

MeSH Terms

Adult
Child
Child, Preschool*
Cyclophosphamide
Cyclosporine
Epidermis
Humans
Immunoglobulins*
Immunoglobulins, Intravenous
Incidence
Korea
Male*
Mortality
Necrosis
Plasmapheresis
Stevens-Johnson Syndrome*
Cyclophosphamide
Cyclosporine
Immunoglobulins
Immunoglobulins, Intravenous