Korean J Dermatol.  2006 Mar;44(3):350-352.

A Case of Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin

• Lee SY
• Choi YS
• You CE
• Park MY
• Son SJ

Abstract

Toxic epidermal necrolysis (TEN) is a rare, life-threatening, mucocutaneous drug reaction, which causes extensive epidermal detachment and serious complications involving ocular structures and internal organs. Recently, intravenous immunoglobulin (IVIG) was suggested to be effective in treating TEN through the blockage of Fas receptors which initiate keratinocyte apoptosis. Herein, we tried IVIG teratment (0.6 g/kg/day for 4 consecutive days) for a case of TEN. As a result, the progression of epidermal detachment was interrupted within 2 days and epithelialization was completed in 3 weeks without significant side effects.

Keyword

Intravenous immunoglobulin; Toxic epidermal necrolysis

MeSH Terms

Antigens, CD95
Apoptosis
Immunoglobulins*
Immunoglobulins, Intravenous
Keratinocytes
Stevens-Johnson Syndrome*
Antigens, CD95
Immunoglobulins
Immunoglobulins, Intravenous