Korean J Pediatr.  2006 Mar;49(3):332-336. 10.3345/kjp.2006.49.3.332.

Steroid and enalapril therapy: possible cause of toxic epidermal necrolysis

• Kim DW
• Jung DE
• Koo JW

• KMID: 2278595
• DOI: http://doi.org/10.3345/kjp.2006.49.3.332

Abstract

Toxic epidermal necrolysis (TEN) is a rare, acute and life-threatening cutaneous drug reaction. TEN is characterized by the sudden onset of extensive necrosis in the epidermis and frequent mucous membrane involvement. The pathogenesis has not yet been elucidated. In addition, no particular treatment for TEN has been established. We report a case of TEN in a 14-year-old-boy, which might have been caused by steroids with enalapril treatment for membranous nephropathy. He recovered after intravenous immunoglobulin therapy.

Keyword

Steroid; Enalapril; Toxic epidermal necrolysis; Intravenous immunoglobulin

MeSH Terms

Enalapril*
Epidermis
Glomerulonephritis, Membranous
Immunization, Passive
Mucous Membrane
Necrosis
Steroids
Stevens-Johnson Syndrome*
Enalapril
Steroids