Keimyung Med J.  2020 Dec;39(2):83-85. 10.46308/kmj.2020.00094.

Toxic Epidermal Necrolysis complicating Infliximab therapy in Refractory Kawasaki disease

Affiliations
  • 1Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea
  • 2Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea

Abstract

Severe skin reactions complicating tumor necrosis factor-alpha (TNF-α) antagonist therapy were somewhat reported in adults. We report a case of 24-month-old boy with refractory Kawasaki disease who developed toxic epidermal necrolysis (TEN) after one dose of 5mg/kg infliximab. The patient responded to intravenous hydrocortisone and was able to discharge without any other serious complications. The clinicians should be aware of the potential for severe skin reactions from the use of TNF-α antagonists in children.

Keyword

Toxic Epidermal Necrolysis; infliximab; Kawasaki disease
Full Text Links
  • KMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr