Korean J Dermatol.
2010 Nov;48(11):913-918.
The Effects of Acer ginnala Leaves Extraction on the Atopic Dermatitis-like Skin Lesions in NC/Nga Mice
- Affiliations
-
- 1Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea. drseo@cau.ac.kr
- 2College of Pharmacy, Chung-Ang University, Seoul, Korea.
- 3College of Medicine, Chung-Ang University, Seoul, Korea.
- 4Division of Marine Molecular Biotechnology, Gangneung-Wonju National University, Wonju, Korea.
Abstract
- BACKGROUND
Atopic Dermatitis (AD) is a chronic relapsing inflammatory skin disease that is usually observed in patients with an individual or familial history of atopic diseases, and AD is precipitated by environmental factors, including mite antigens. AD is known to be generated by an imbalance of both Th1 and Th2 cytokines. However, the exact etiology of AD is unclear. The leaves of Acer ginnala (AGL) have been demonstrated to have an anti-oxidant effect.
OBJECTIVE
We wanted to investigate the effect of AGL on AD-like skin lesions and the other factors related to an immune response.
METHODS
The AGL was applied to the AD-like skin lesions on the backs of NC/Nga mice. The efficacy of AGL in the NC/Nga mice was evaluated by the changes of severity of the skin lesions (a modified SCORAD). Blood was collected from the retro-orbital area and the abdominal vena cava. The levels of eosinophils, immunoglobulin (Ig) E and Th2-related cytokines in the blood were measured.
RESULTS
The topical application of AGL suppressed the development of AD-like skin lesions. The percent of blood eosinophils was decreased after treatment with AGL. The serum IgE and Th2-related cytokine levels were decreased after treatment with AGL compared with those treated with base cream (the vehicle treated AD group). The IL-4, IL-5 and IL-13 levels were lower than those of the vehicle treated AD group.
CONCLUSION
The findings suggest that AGL may exert an inhibitory effect on atopic dermatitis.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Developing an Atopic Dermatitis Model and the Effects of Actinidia Extract on Dermatitis in NC/Nga Mice
- Therapeutic Effects of Light Emitting Diode on Atopic Dermatitis-Like Lesions in NC/Nga Mice
- Topical Application of Eupatilin Ameliorates Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice
- A Study on Tests of Skin Safety and Inhibition of Atopic Dermatitis Using a StoneTouch(R) Infrared Scanner in a Mouse Model
- Inhibitory effects of interleukin-10 plasmid DNA on the development of atopic dermatitis-like skin lesions in NC/Nga mice
