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Current Update of Local Allergic Rhinitis

Kim SJ, Moon JW, Lee HM

Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy. The symptoms, duration, severity, and comorbidities of LAR are similar to those of allergic...
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Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

Piao CH, Fan YJ, Nguyen TV, Yu ZN, Shin HS, Song CH, Chai OH

Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi...
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Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 Years

Kim YJ, Lee MY, Yang AR, Sol IS, Kwak JH, Jung HL, Shim JW, Kim DS, Shim JY

Purpose: Climate and lifestyle changes increase an individual’s susceptibility to various allergens and also the incidence of allergic diseases. We aimed to examine the changes in sensitization rate for aeroallergens...
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Virus-like Particle (VLP) Mediated Antigen Delivery as a Sensitization Tool of Experimental Allergy Mouse Models

Kim J, Oh J, Kang CS, Choi YS

Antigen delivery systems play critical roles in determining the quality and quantity of Ab responses in vivo. Induction of protective antibodies by B cells is essential in the development of...
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In Vitro and In Vivo Validation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity

Plaza J, Torres R, Urbano A, Picado C, Mora Fd

Purpose: Agonism of the prostaglandin E2 receptor, E-prostanoid receptor 2 (EP2), may represent an alternative protective mechanism in mast cell (MC)-mediated diseases. Previous studies have suggested that activation of the...
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Combined Effects of Lactobacillus rhamnosus and Egg Oral Immunotherapy in a Mouse Model of Egg Allergy

Kim BG, Kim JN, Jang AS, Shin M

Purpose: Recent clinical trials have successfully used oral immunotherapy (OIT) to treat food allergies. Probiotics have immunomodulatory effects by balancing Th1/Th2 immunity and enhancing regulatory T-cell activity. In this study,...
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Inhibition of Cross-Reactive Carbohydrate Determinant–Specific IgEs Reduce False Positive Reponses to Multiple Allergen Simultaneous Test–Immunoblot Assay: A Case Study

Song DY, Lee JH, Kim SM, Jun SH, Lee K, Song SH, Song J

Cross-reactive carbohydrate determinants (CCDs) are simple carbohydrates linked to amino acid chains; they are found in pollens, vegetable foods, insect, and Hymenoptera venoms and are broadly cross-reactive with CCD-specific IgE...
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Sestrin2 Mediates IL-4-induced IgE Class Switching by Enhancing Germline ε Transcription in B Cells

Shim YS, Lee S, Park HW, Park SR

Sestrin2 (Sesn2), a metabolic regulator, accumulates in response to a diverse array of cellular stresses. Sesn2 regulates cellular metabolism by inhibiting the mammalian target of rapamycin complex 1 through the...
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Clinical and Laboratory Findings of Barley Allergy in Korean Children: a Single Hospital Based Retrospective Study

Lee E, Jeong K, Lee J, Jeon SA, Park B, Lee H, Lee S

BACKGROUND: Barley is a grain that is consumed in various forms in Asia. Studies on barley allergy are limited to a few case reports about hypersensitivity reactions to beer, but...
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Survey of IgE Reactivity to Nonbiting Midges in Korea and Identification of IgE-Binding Protein

Yi MH, Kim JY, Jeong KY, Ree HI, Yong TS

PURPOSE: Chironomids (nonbiting midges) are widely and abundantly distributed near ponds, rivers, and artificially dammed pools used for irrigation. Chironomids contain allergens and cause airway allergy in humans. In this...
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Anti-atopic dermatitis effect of the soybean fermented by B. amyloliquefaciens via inhibiting IL-31

Hong S, Hwang SW, Yang HJ, Jeong DY, Kim O

The occurrence of allergic disease has increased harmfully in the last few decades. Atopic dermatitis (AD) is an allergic inflammation disorder characterized by itchy, red, swollen, cracked skin. Although the...
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Evaluation of multiple allergen simultaneous (sIgE) testing compared to intradermal testing in the etiological diagnosis of atopic dermatitis in horses

Wilkołek , Szczepanik M, Sitkowski , Rodzik B, Pluta M, Taszkun I, Gołyński M

Although intradermal testing (IDT) is commonly used in the etiological diagnosis of allergies, in vitro testing for specific IgE (sIgE) is an attractive alternative. Currently, new laboratory techniques in veterinary...
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Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by In Vitro and In Vivo Tests

Sánchez J, Sánchez A, Cardona R

PURPOSE: Immunoglobulin (Ig) E autoantibodies against thyroid antigens such as thyroid peroxidase (TPO) have been demonstrated in chronic spontaneous urticaria (CSU) patients in higher frequency than healthy subjects. However, if...
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Immunoglobulin E-binding Proteins of Cooked Walnuts in Korean Children

Lee J, Jeong K, Jeon SA, Lee S

PURPOSE: The immunological characteristics of young Korean children with walnut (WN) allergy and the influence of different cooking methods on WN proteins have not been evaluated to date. This study...
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Allergen Microarrays for In Vitro Diagnostics of Allergies: Comparison with ImmunoCAP and AdvanSure

Jeon H, Jung JH, Kim Y, Kwon Y, Kim ST

BACKGROUND: In vitro detection of the allergen-specific IgE antibody (sIgE) is a useful tool for the diagnosis and treatment of allergies. Although multiple simultaneous allergen tests offer simple and low-cost...
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Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485

Rakhmanova V, Jin M, Shin J

Mast cells integrate innate and adaptive immunity and are implicated in pathophysiological conditions, including allergy, asthma, and anaphylaxis. Cross-linking of the high-affinity IgE receptor (FcεRI) initiates diverse signal transduction pathways...
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Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells

Lee SH, Park SR

Interaction between pathogen-associated molecular patterns and pattern recognition receptors triggers innate and adaptive immune responses. Several studies have reported that toll-like receptors (TLRs) are involved in B cell proliferation, differentiation,...
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Clinical validation of ImmuneCheck IgE for the rapid detection of serum total IgE

Lee S, Choi J, Choe E, Lee SC, Park KH, Lee JH, Park JW

PURPOSE: Conventional serum IgE assay was costly, required the skills of expert, and relied heavily on expensive equipment. Quantitative measurement of total IgE using Point of Care Test (POCT) device...
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Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy

Nam YH, Lee SH, Rhyou HI, Lee YS, Park SH, Lee YH, Shin YS, Park HS, Ye YM

PURPOSE: Cefaclor, a second-generation oral cephalosporin, is known to cause IgE-mediated hypersensitivity. Assays of serum-specific IgE (sIgE) to cefaclor are commercially available via the ImmunoCAP system (Thermo Fisher Scientific). While...
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Detecting Allergens From Black Tiger Shrimp Penaeus monodon That Can Bind and Cross-link IgE by ELISA, Western Blot, and a Humanized Rat Basophilic Leukemia Reporter Cell Line RS-ATL8

Jarupalee , Chatchatee P, Komolpis K, Suratannon N, Roytrakul , Yingchutrakul Y, Yimchuen W, Butta P, Jacquet A, Palaga T

BACKGROUND: Black tiger shrimp Penaeus monodon is one of the common causes of shellfish allergy that is increasing worldwide. One of the important problems in the management of shellfish allergy...
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