Korean J Audiol.  2012 Apr;16(1):14-17. 10.7874/kja.2012.16.1.14.

Effect of Isoflurane on the Hearing in Mice

• Kim JU
• Ahn YS
• Suh JK
• Chung JW

• KMID: 2299818
• DOI: http://doi.org/10.7874/kja.2012.16.1.14

Abstract

BACKGROUND AND OBJECTIVES
The aim of this study was to investigate the relationship between inhalation anesthetics and hearing in mice.
MATERIALS AND METHODS
As inhalation anesthetics, isoflurane was used. Auditory brainstem response and distortion product otoacoustic emission were used as measurement of hearing. Mice were divided into 2 groups. 'Isoflurane group' consisted of mice that were anesthetized with an inspired concentration of 2.0 vol% isoflurane with 2 L/min of oxygen (n=10). 'Control group' consisted of mice that were anesthetized with ketamine and xylazine (n=10).
RESULTS
Auditory brainstem response thresholds in mice anesthetized with ketamine and xylazine was not different from those in mice anesthetized with isoflurane. Threshold of DPOAE was higher in mice with isolurane than with ketamine and xylazine. Changes of efferent control may be induced by isoflurane and consequently change the threshold of DPOAE in mice.
CONCLUSIONS
These results infer that, there was a change of central nervous system induced by inhalation anesthetics, this change also can be applied to the strategies for prevention of hearing loss.

Keyword

Hearing; Anesthetics; Central nervous system; Efferent control

MeSH Terms

Anesthetics
Anesthetics, Inhalation
Animals
Central Nervous System
Evoked Potentials, Auditory, Brain Stem
Hearing
Hearing Loss
Isoflurane
Ketamine
Mice
Oxygen
Xylazine
Anesthetics
Anesthetics, Inhalation
Isoflurane
Ketamine
Oxygen
Xylazine