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A Novel Heterozygous Missense Variant (c.667G>T;p.Gly223Cys) in USH1C That Interferes With Cadherin-Related 23 and Harmonin Interaction Causes Autosomal Dominant Nonsyndromic Hearing Loss

Song JS, Bahloul A, Petit C, Kim SJ, Moon IJ, Lee J, Ki CS

BACKGROUND: Pathogenic variants of USH1C, encoding a PDZ-domain-containing protein called harmonin, have been known to cause autosomal recessive syndromic or nonsyndromic hearing loss (NSHL). We identified a causative gene in...
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Cortical Deafness and Tinnitus Following Sequential Bilateral Putaminal Hemorrhage

Yang S, Chen S, Zhu J, Han X

No abstract available.
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Clinical and Genetic Spectrum of ATP1A3-Related Disorders in a Korean Pediatric Population

Kim WJ, Shim YK, Choi SA, Kim SY, Kim H, Hwang H, Choi J, Kim KJ, Chae JH, Lim BC

BACKGROUND AND PURPOSE: The aim of this study was to expand the understanding of the genotype-phenotype spectrum of ATP1A3-related disorders and to evaluate the therapeutic effect of a ketogenic diet...
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The Influence of Education Level on Tinnitus and Quality of Life in Korean Adults

Jung DJ, Yoo MH, Jung YJ, Lee HJ, Lee KY

BACKGROUND AND OBJECTIVES: We aimed to evaluate the effect of the level of education on the prevalence of tinnitus and quality of life (QoL) in the Korean population. SUBJECTS AND METHOD:...
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Two Cases of Pediatric Pneumolabyrinth with Traumatic Tympanic Membrane Perforation after Penetrating Injury

You YS, Koh JH, Kim BJ, Lee EJ

Pneumolabyrinth is an uncommon condition in which air is present in the vestibule or cochlear. It is rarely found, even in otic capsule violating fractures or in transverse fracture of...
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Applications of photobiomodulation in hearing research: from bench to clinic

Lee JH, Kim S, Jung JY, Lee MY

Hearing loss is very common and economically burdensome. No accepted therapeutic modality for sensorineural hearing loss is yet available; most clinicians emphasize rehabilitation, placing hearing aids and cochlear implants. Photobiomodulation...
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A Case of Autoimmune Sensorineural Hearing Loss Responding to Cytotoxic Agent

Lee YW, Lee J, Kim MB, Chang SO

Autoimmune sensorineural hearing loss is a rare disease characterized by bilateral sensorineural hearing loss, some in a progressive pattern and others in idiopathic or fluctuating pattern, often accompanied by vestibular...
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Correlation between Auditory Brainstem Response Characteristics and Hearing Recovery in Sudden Deafness

Lim EJ, Shin J, Kim TH, Park JH, Kim S

BACKGROUND AND OBJECTIVES: Auditory brainstem response (ABR) can be utilized to verify the hearing threshold and determine the existence of retrocochlear pathology in sudden deafness. However, little is known about...
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Characteristics of Delirium in Patients with Hearing Disturbances

Jo YT, Joo SW, Lee J, Joo YH

OBJECTIVES: Several studies have delineated the relationship between hearing disturbances and the prevalence or characteristics of psychotic symptoms; however, most of those studies focused on psychiatric patients and not general...
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Abrupt Change in Electrophysiological Properties Begins From Postnatal Day 7 Before Hearing Onset in the Developing Mice Auditory Cortical Layer II/III Neurons

Ahn SC

OBJECTIVES: In the developing auditory cortex, maturation of electrophysiological properties and cell types before and after hearing onset has been reported previously. However, the exact timing of firing pattern change...
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Decreased Aquaporin 4 and 6 mRNAs in Patients With Chronic Otitis Media With Otorrhea

Kim JH, Kim SS, Kim YI, Jung SY, Kim SH, Yeo SG

OBJECTIVES: Aquaporins (AQPs) are integral membrane proteins engaged in the modulation of water homeostasis, but the roles they play in chronic otitis media (COM) have not been well investigated. Accordingly,...
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Bilateral Hearing Loss in Wernicke Encephalopathy

Bae H, Park JY, Cho HS, Lim SH, Ha SW

Wernicke encephalopathy is a syndrome caused by thiamine deficiency whose three typical symptoms are ophthalomoplegia, ataxia, and confusion. There are also rare reports of bilateral hearing loss, which can be...
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Severe Temporal Hyper-Activated States Caused by Noise in Tinnitus and Hyperacusis with Normal Hearing

Bae EB, Lee JH

Lots of neuroimaging and animal studies have revealed that tinnitus and hyperacusis share the same patterns in the bottom up central auditory process. The aim was to identify the abnormal...
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Effects of Residual Hearing on the Auditory Steady State Response for Cochlear Implantation in Children

Kim YS, Han SA, Woo H, Suh MW, Lee JH, Oh SH, Park MK

BACKGROUND AND OBJECTIVES: We aim to explore the effects of residual auditory steady state response (ASSR) on cochlear implantation (CI) outcomes in children lacking auditory brainstem responses (ABRs). SUBJECTS AND METHODS:...
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Microscopic versus Endoscopic Inlay Butterfly Cartilage Tympanoplasty

Lee SA, Kang HT, Lee YJ, Kim BG, Lee JD

BACKGROUND AND OBJECTIVES: Inlay butterfly cartilage tympanoplasty makes the graft easy, and reduces operating time. The present study aimed to investigate the outcomes of microscopic versus endoscopic inlay butterfly cartilage...
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Educational Status in Bilateral Prelingual Deaf Children with Cochlear Implantation

Bae SH, Kwak SH, Nam GS, Choi JY

BACKGROUND AND OBJECTIVES: This study was undertaken to investigate the educational status in bilateral prelingual deaf children with a cochlear implant (CI), also known as early cochlear implantees (CIs). Type...
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Translation, Adaptation and Cross-Cultural Validation of Hearing Handicap Inventory for Adult in Malay Language

Zam Zam TZ, Dzulkarnain AAA, Rahmat S, Jusoh M

BACKGROUND AND OBJECTIVES: Sine a self-reported questionnaire for hearing-impaired listeners is not available by Malay language yet, it is important to develop or translate any available existing questionnaires. The aim of...
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The Influence of Feedback in the Simulated Patient Case-History Training among Audiology Students at the International Islamic University Malaysia

Dzulkarnain AAA, Sani MK, Rahmat S, Jusoh M

BACKGROUND AND OBJECTIVES: There is a scant evidence on the use of simulations in audiology (especially in Malaysia) for case-history taking, although this technique is widely used for training medical...
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Auditory Cortical Temporal Processing and Hemispheric Asymmetry Revealed by N1 Dipole Source Activity in Adult Cochlear Implant Users

Lee J, Han JH, Lee HJ

BACKGROUND AND OBJECTIVES: Cochlear implant (CI) changes the way that sound inputs are processed in the brain, possibly causing brain reorganization. Given that the pattern and degree of reorganization are...
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Comparison of Intratympanic, Systemic, and Combined Steroid Therapies for Sudden Sensorineural Hearing Loss in Patients with Diabetes Mellitus

Kim HJ, Lee YJ, Kang HT, Lee SA, Lee JD, Kim BG

BACKGROUND AND OBJECTIVES: We investigated whether the intratympanic steroid injections might be an effective initial treatment for sudden sensorineural hearing loss (SSNHL) in patients with diabetes mellitus (DM). SUBJECTS AND METHOD:...
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