Korean J Anesthesiol.
1992 Dec;25(6):1206-1211. 10.4097/kjae.1992.25.6.1206.
Effect of Clonidine Premedication on Isoflurane Induced Hypotensive Anesthesia
- Affiliations
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- 1Department of Anesthesiology, College of Medicine, University of Ulsan, Korea.
- KMID: 1934115
- DOI: http://doi.org/10.4097/kjae.1992.25.6.1206
Abstract
- The effect of single dose clonidine premedication on the vapour requirement for isoflurane induced hypotension in 20 patients undergoing spine surgery was evaluated. The patients given 5 ug/kg of clonidine P.O. at 90 minutes before operation required a mean expired isoflurane concentration of 1.2+/-0.5 vol% to induce hypotension compared with 2.1+/-0.6 vol% in 0.2 mg/kg of diazepam predmedication group(P<0.05). To achieve satisfactory hypotension, six out of ten patients in diazepam premedication group and l out of 10 patients in clondine premedication group are required supplementary infusion of sodium nitroprusside. In conclusion, clonidine premedication is recommended in isoflurane induced hypotensive anesthesia.
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