Korean J Anesthesiol.  2010 Apr;58(4):374-377. 10.4097/kjae.2010.58.4.374.

Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of cAMP

• Chang CH
• Roh GU
• Park WK

• KMID: 2299336
• DOI: http://doi.org/10.4097/kjae.2010.58.4.374

Abstract

BACKGROUND
Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate).
METHODS
The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin) of each step of beta-adrenoceptor-mediated cascades.
RESULTS
While the production of cAMP stimulated by isoproterenol, GTPgammaS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 micrometer) did not alter the levels of cAMP.
CONCLUSIONS
Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPgammaS, and forskolin, propofol appears to have no effect on the beta-adrenoceptor signaling pathway in guinea pig ventricular myocardium.

Keyword

beta-adrenoceptor; cAMP; G-protein; Propofol

MeSH Terms

Adenosine
Animals
Forskolin
GTP-Binding Proteins
Guanosine 5'-O-(3-Thiotriphosphate)
Guinea Pigs
Isoproterenol
Myocardium
Propofol
Signal Transduction
Adenosine
Forskolin
GTP-Binding Proteins
Guanosine 5'-O-(3-Thiotriphosphate)
Isoproterenol
Propofol