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Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation

Tsai YC, Cheng TS, Liao HJ, Chuang MH, Chen HT, Chen CH, Zhang KL, Chang CH, Lin PC, Huang CYF

BACKGROUND: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have...
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Characteristics of patients with ruptured very small intracranial aneurysm sized less than 3 mm

Park GT, Kim JH, Jung YJ, Chang CH

Objective: If the size of an intracranial aneurysm is below 3 mm, clinicians rarely treat them because of the low risk of rupture. But subarachnoid hemorrhage (SAH) due to the...
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Changes in Glucose Metabolism after Adrenalectomy or Treatment with a Mineralocorticoid Receptor Antagonist for Primary Aldosteronism

Lin YF, Peng KY, Chang CH, Hu YH, Wu VC, Chung SD, Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group

Background: Data on the effects of excess aldosterone on glucose metabolism are inconsistent. This study compared the changes in glucose metabolism in patients with primary aldosteronism (PA) after adrenalectomy or...
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The Effect of Reform of New Diagnosis-Related Groups on Coverage of National Health Insurance

Choi JK, Kim SH, Chang CH, Yoon JM, Kang JG

Background: Korea set up a new diagnosis-related group as a demonstration project in 2009. The new diagnosis-related group was reformed in 2016. The main purpose of the study is to...
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Hyaluronan Induces a Mitochondrial Functional Switch in Fast-Proliferating Human Mesenchymal Stem Cells

Solis MA, Wei YH, Chang CH, Yu CH, Huang LL

Background and Objectives: Hyaluronan preserves the proliferation and differentiation potential of mesenchymal stem cells. Supplementation of low-concentration hyaluronan (SHA) in stem cells culture medium increases its proliferative rate, whereas coated-surface...
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Efficacy of dual antiplatelet therapy as premedication before diagnostic cerebral digital subtraction angiography

Choo YH, Jung YJ, Chang CH, Kim JH

OBJECTIVE: Several studies have reported that periprocedural dual antiplatelet therapy lowers the incidence of thromboembolic complications (TEC) associated with coiling of unruptured aneurysms. We hypothesized that preprocedural administration of dual...
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The learner-adjusted assessment tool for endotracheal intubation considering examiners' different expectations of competence

Kang HY, Han KS, Lee SW, Choi HJ, Lim TH, Kim CW, Chang CH, Kim SJ

OBJECTIVE: Endotracheal intubation (ETI) is the most reliable way to manage the airway. Stepwise deliberate practice and mastery training is essential in maintaining and promoting the skill of intubation. This...
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Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide populationbased study

Yen HH, Weng MT, Tung CC, Wang YT, Chang YT, Chang CH, Shieh MJ, Wong JM, Wei SC

BACKGROUND/AIMS: Incidences of inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn’s disease (CD), have been increasing in Asia. In this study, we report the relevant clinical characteristics and determined...
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Technical Consideration for Coiling of Ruptured Proximal Posterior Inferior Cerebellar Artery Aneurysm

Kim JH, Jeon IC, Chang CH, Jung YJ

OBJECTIVE: Surgical obliteration of ruptured aneurysm of the proximal posterior inferior cerebellar artery (PICA) is challenging because of limited surgical accessibility. In recent years, coil embolization is the first-choice treatment...
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A Pseudoaneurysm Associated with a Ruptured Cerebral Aneurysm: Hypothesis on the Formation of the PA and Feasibility of Endovascular Treatment

Kim JH, Chang CH, Jung YJ

An intracranial pseudoaneurysm (PA) is a very rare disease and is known to occur in less than 1% of intracranial aneurysms. The pathophysiology and the modality of the proper treatment...
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Evaluation of the Accuracy in Maximum Intensity Projection Images of Cerebral Computed Tomographic Angiography for the Diagnosis of Cerebral Vasospasm Following Subarachnoid Hemorrhage, in Comparison to Digital Subtraction Angiography

Kim JH, Yi JH, Chang CH, Jung YJ

OBJECTIVE: The purpose of this retrospective study is to determine the accuracy of maximum intensity projection (MIP) images of computed tomographic angiography (CTA) for diagnosis of cerebral vasospasm (CV) following...
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The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease

Yarosz EL, Chang CH

T lymphocytes rely on several metabolic processes to produce the high amounts of energy and metabolites needed to drive clonal expansion and the development of effector functions. However, many of...
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Simultaneous Onset of Ischemic and Hemorrhagic Stroke Due To Intracranial Artery Dissection

Kim JH, Jung YJ, Chang CH

Intracranial dissections commonly present as ischemic stroke and as hemorrhagic stroke. In general, while either ischemic stroke or hemorrhagic stroke may develop, the simultaneous onset of both may also occasionally...
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Fluoroscopy-guided Combined (Surgical/Endovascular) Treatment of Dural Arteriovenous Fistula

Park SH, Kim JH, Chang CH, Jung YJ

For dural arteriovenous fistula (DAVF), when the usual endovascular or neurosurgical approaches are difficult to treat, multi-modal treatment can be helpful. We present a case of a 71-year-old woman with...
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Spontaneous Pseudoaneurysm of the Proximal Occipital Artery Presenting as a Neck Mass

Kim TG, Lee JH, Chung KJ, Lee JH, Kim YH, Chang CH

No abstract available.
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Normal aging: definition and physiologic changes

Chang CH, Lee KY, Shim YH

Aging is a process of the progressive functional decline with time, leading to disability, dependence, morbidity, and mortality. While the organ function in the elderly is relatively uncompromised under basal...
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Update of the Korean Clinical Practice Guidelines for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke

Hong KS, Ko SB, Yu KH, Jung C, Park SQ, Kim BM, Chang CH, Bae HJ, Heo JH, Oh CW, Lee BC, Kim BT, Kim BS, Chung CS, Yoon BW, Rha JH

Patients with severe stroke due to acute large cerebral artery occlusion are likely to be severely disabled or die if reperfusion is not achieved in a timely manner. Intravenous tissue...
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Procedure-related Complication Rate for the Endovascular Treatment of Aneurysmal Subarachnoid Hemorrhage under Local Anesthesia

Park SD, Kim JH, Chang CH, Jung YJ

OBJECTIVE: To report the procedure related complication rate of endovascular treatments (EVTs) performed on patients with aneurysmal subarachnoid hemorrhage (aSAH) under local anesthesia (LA). MATERIALS AND METHODS: This study enrolled 186...
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Effect of Cervical Interlaminar Epidural Steroid Injection: Analysis According to the Neck Pain Patterns and MRI Findings

Choi JW, Lim HW, Lee JY, Lee WI, Lee EK, Chang CH, Yang JY, Sim WS

BACKGROUND: It is widely accepted that cervical interlaminar steroid injection (CIESI) is more effective in treating radicular pain than axial neck pain, but without direct comparison. And the differences of...
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Update of the Korean Clinical Practice Guidelines for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke

Hong KS, Ko SB, Yu KH, Jung C, Park SQ, Kim BM, Chang CH, Bae HJ, Heo JH, Oh CW, Lee BC, Kim BT, Kim BS, Chung CS, Yoon BW, Rha JH

Patients with severe stroke due to acute large cerebral artery occlusion are likely to be severely disabled or dead without timely reperfusion. Previously, intravenous tissue plasminogen activator (IV-TPA) within 4.5...
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